- Published: Monday, 21 September 2020 11:15
- Hits: 44
- Published: Wednesday, 16 September 2020 12:28
- Hits: 78
- Published: Wednesday, 02 September 2020 16:07
- Hits: 176
A warm welcome to the new NRUs:
Research Assistant Kristian Reveles Jensen, MD, who will be working in the BrainDrugs project.
Project employee Louise Nielsen, Psychologist.
Music Therapist Catharina Messell, who will be working with Dea.
Scholarstipend students Anna Søndergaard and Elisabeth Pedersen (both Medicine).
Intern Cecilie Poulsen, Medical Technologist student. She will be working in the SPECT lab.
Volunteers Inger Sørensen (Medicine) and Maria Grzywacz (Psychology)
Philip Fink-Jensen is now scholarstipend student, and Sophia Weber is back as a master's student.
Anna Catharina Cecilie Elisabeth
Inger Kristian Maria
- Published: Friday, 28 August 2020 12:28
- Hits: 197
- Published: Tuesday, 25 August 2020 09:06
- Hits: 226
- Published: Wednesday, 01 July 2020 16:19
- Hits: 716
Neurosurgery for brain tumours and epilepsy requires a delicate balance between removal of sufficient pathological tissue to postpone disease progression/relieve symptoms and limiting resections where damage would cause impairment of important brain function, such as motor ability and language. Neurosurgery has always included stimulation of the exposed brain in patients operated when awake for registration of the neuropsychological and functional responses to localize essential functions. However, direct stimulation requires the patient’s ability to cooperate and is further limited by the growing use of minimally invasive surgery, where the brain surface is no longer exposed. With our new approach, we wish to pave the way to brain mapping that is adaptable to anaesthetized patients and can be used with less invasive surgery techniques. We will first focus on preoperative magnetic resonance (MR) session to map malignant tumour spread as well as areas with essential functions, and will compare findings with positron emission tomography of amino acid uptake to delineate malignancy. Further, an intraoperative MR approach for localizing essential functions will be used to guide the ongoing surgical plan both in patients with brain tumours and epilepsy. Results will be compared to operative and clinical findings and histopathological tissue properties.
- Published: Thursday, 18 June 2020 08:04
- Hits: 629
Electroceutical therapy is a rapidly expanding therapeutic option used in diverse medical conditions. Our patented device, the fMRI Compatible Electrical Stimulator, can measure the effects of electric stimuli with functional magnetic resonance
imaging (fMRI). Now we want to develop and commercialize our product by generating a regulatory strategy, conducting a market analyses and a Development Plan to support an approval of the product in key markets. Moreover, we will build
an improved control unit of the prototype and conduct clinical pilot studies relevant for two different applications.
- Published: Tuesday, 02 June 2020 16:11
- Hits: 692
- Published: Friday, 29 May 2020 12:07
- Hits: 708
Summary of Gjertrud's 1-year project:
Developing drugs for treatment of brain disorders is challenging, time consuming and costly. PET neuroimaging has evolved as a useful tool for investigating the interactions between a drug and its target receptor in the human brain. Although PET is frequently used for drug development, the experimental framework and methodologies used to analyze the acquired data are inefficient, often leading to biased outcomes and high variability. With improved analytical techniques it will be possible to modify the experimental setup so that the number of PET scans can be reduced without sacrificing statistical power.
Current analytical tools require that at least two scans, one at baseline and one after administration of the drug, are acquired for each research subject. We aim to improve the utility of PET for drug development by establishing methods that enable within-scan challenges, in which the drug is administered during an ongoing scan. Such a setup circumvents the issue of biological fluctuations between scans, while also reducing costs and lowering the total radiation exposure. However, in order to employ this experimental design a new class of pharmacokinetic models must be developed, because current models are adequate only for separate scans. In this project, we plan to develop new mathematical models that describe the pharmacokinetics of the PET ligand before, during and after administration of a drug competing for the same receptor. We will validate these models using simulation experiments and real PET data.
- Published: Thursday, 28 May 2020 10:09
- Hits: 754
More Articles ...
- New funding for NRU from Independent Research Fund Denmark
- MRI and SPECT scanning in the North Wing
- PhD stipend to Stinne Høgh
- International post doc grant from IRFD
- Staff News, March 2020
- Scholarstipend from DSfN
- Funding from Lægefonden to Lene Donovan
- Grant from Novo Nordisk Foundation
- Bias and fairness in medicine
- NRU research in Deadline on DR2