Yu-Shiuan Lin

Scientific interests

My research interests center on probing how adenosine signaling modulates neurotransmission, neural plasticity, as well as sleep behaviors and neurocognitive functions using caffeine. My previous work has employed structural and task‑based fMRI, receptor PET imaging, polysomnography, and neurocognitive behavioral assessments within randomized controlled trial designs. During my early postdoctoral training, I also engaged in preclinical research investigating adenosine-dopamine interactions in nonhuman primates and rodents using D1 and D2 receptor PET.

At the NRU, I will be analyzing SV2A PET data to determine the effects of time of day and to evaluate test-retest variability. Moreover, I will use NIRS to examine the effects of caffeine on brain water dynamics to elucidate the role of adenosine in sleep-dependent glymphatic activity.

Biography

Publications

(^f Correspondence author)

• Yoo, C.-H., Xu, Y., Bagdasarian, F. A., Lin, Y.-S., Wang, C., Wey, H.-Y. Cannabinoid 1 Receptor Occupancy and Neurovascular responses Induced by Agonist, Antagonist, and Potential Modulator in Non-Human Primate Brains: PET/fMRI study. Journal of cerebral blood flow and metabolism. Journal of cerebral blood flow and metabolism. 2025 Nov 3:271678X251389042. doi: 10.1177/0271678X251389042.
• Pearson, T., Bricault, S., Lin, Y.-S., Moore, K. E., Wey, H.-Y^f. (2025) Preclinical PET imaging of the developing fetus during pregnancy: Current state and future potential. Journal of cerebral blood flow and metabolism. 2025 May 14:271678X251340510. doi: 10.1177/0271678X251340510.
• Lin, Y.-S.,^f Lange, D., Baur, D.-M., Foerges, A., Chu, C., Li, C., Elmenhorst, E.-M., Neumaier, B., Bauer, A., Aeschbach, D., Landolt, H.-P., Elmenhorst, D^f. (2024) Repeated caffeine intake suppresses cerebral grey matter responses to chronic sleep restriction in an A₁adenosine receptor-dependent manner: a double-blind randomized controlled study with PET-MRI. Scientific reports, 14(1):12724. doi: 10.1038/s41598-024-61421-8.
• Yoo, C.-H., Rani, N., Shen, S., Loggia, M. L., Gaynor, K., Moore, K.E., Bagdasarian, F. A., Lin, Y.-S., Edwards, R. R., Price, J. C., Hooker, J. M., & Wey, H.-Y^f. (2024) Investigating neuroepigenetic alterations in chronic low back pain with positron emission tomography. Epub. doi: 10.1097/j.pain.0000000000003272.
• Lin, Y.-S.,^f Weibel, J., Landolt, H.-P., Santini, F., Slawik, H., Borgwardt, S., Cajochen, C.,^f & Reichert, C. F. (2023) Brain activity during a working memory task after daily caffeine intake and caffeine withdrawal: a randomized double-blind placebo-controlled trial. Scientific reports 13, 1002, doi:10.1038/s41598-022- 26808-5.
• Lin, Y.-S., Weibel, J., Landolt, H.-P., Santini, F., Garbazza, C., Kistler, J., Rehm, S., Rentsch, K., Borgwardt, S., Cajochen, C.,^f & Reichert, C. F. (2022). Time to Recover from Daily Caffeine Intake. Frontiers in Nutrition, 8. https://doi.org/10.3389/fnut.2021.787225.
• Lin, Y.-S., Wey, H.-Y., Cajochen, C., Reichert, C. (2021) Effects of acute and daily caffeine on positive and negative reinforcement learning. Scientific Reports. Accepted for Stage 1 Registered Report.
• Reichert, C. F.,^f Veitz, S., Bühler, M., Gruber, G., Deuring, G., Rehm, S. S., Rentsch, K., Garbazza, C., Meyer, M., Slawik, H., Lin, Y. S., & Weibel, J. Wide awake at bedtime? Effects of caffeine on sleep and circadian timing in male adolescents - A randomized crossover trial. Biochemical pharmacology, 114283, doi:10.1016/j.bcp.2020.114283 (2020).
• Lin, Y.-S., Weibel, J., Landolt, H.-P., Santini, F., Meyer, M., Brunmair, J., Meier-Menches, S. M., Gerner, C., Borgwardt, S., Cajochen, C.^f & Reichert, C. Daily Caffeine Intake Induces Concentration-Dependent Medial Temporal Plasticity in Humans: A Multimodal Double-Blind Randomized Controlled Trial. Cerebral Cortex 31, 3096-3106, doi:10.1093/cercor/bhab005 (2021).
• Weibel, J., Lin, Y. S., Landolt, H. P., Berthomier, C., Brandewinder, M., Kistler, J., Rehm, S., Rentsch, K. M., Meyer, M., Borgwardt, S., Cajochen, C.^f & Reichert, C. F. Regular Caffeine Intake Delays REM Sleep Promotion and Attenuates Sleep Quality in Healthy Men. Journal of biological rhythms, 7487304211013995, doi:10.1177/07487304211013995 (2021).
• Weibel, J., Lin, Y. S., Landolt, H. P., Kistler, J., Rehm, S., Rentsch, K. M., Slawik, H., Borgwardt, S., Cajochen, C.^f & Reichert, C. F. The impact of daily caffeine intake on nighttime sleep in young adult men. Scientific reports 11, 4668, doi:10.1038/s41598-021-84088-x (2021).
• Weibel, J., Lin, Y. S., Landolt, H. P., Garbazza, C., Kolodyazhniy, V., Kistler, J., Rehm, S., Rentsch, K., Borgwardt, S., Cajochen, C.^f & Reichert, C. F. Caffeine-dependent changes of sleep-wake regulation: Evidence for adaptation after repeated intake. Progress in neuro-psychopharmacology & biological psychiatry 99, 109851, doi:10.1016/j.pnpbp.2019.109851 (2020).

Book chapter

• Lin, Y.-S., Fusar-Poli, P., & Borgwardt, S. (2019). Neuroimaging and the At-Risk Mental State. In Neuroimaging of Schizophrenia and Other Primary Psychotic Disorders (pp. 219-265). Springer International Publishing. https://doi.org/10.1007/978-3-319- 97307-4_6.

Under-review journal papers

• Lin, Y.-S., Yoo, C.-H., Bagdasarian, F. A., Tokala, R., Downey, J. W., Wey, H.-Y. Acute Caffeine Enhances Striatal Dopamine D2/D3 Receptor Availability and Dopamine Release in Nonhuman Primates. (under review)
• Lin, Y.-S., Bricault, S., Gaynor, K., Yoo, C.-H., Pearson, T. D., Barusso, E., Bagdasarian, F. A., Mandeville, J., Wey, H.-Y. Acute and Chronic Caffeine Reduces [¹¹C]Raclopride Uptake in Rats: Implications of a Species Difference in Adenosine-Dopamine Modulation. Journal of Translational Medicine. (under review)
• Bricault, S., Gaynor, K., Yoo, C.-H., Barusso, E., Bagdasarian, F. A., Lin, Y.-S., Pearson, T. D., Bodangi, S., McQuade, P., Knight, A., Winkelmann, C., Wey, H.-Y. Longitudinal characterization of acute and chronic lipopolysaccharide rat models of neuroinflammation using [¹¹C]PBR28 and [¹¹C]BRD1158. Journal of cerebral blood flow and metabolism. (under review)

Awards