Neurobiology Research Unit

Morten Ziebell

MD, PhD Student

Scientific interests

Clinical SPECT.

Since 2002, I’ve been working in our SPECT laboratory. My research has primarily been concentrated on the dopamine system in movement disorders and on how SPECT imaging in early stages of disease can contribute to a final diagnosis. Through my research, I’ve been dealing with SPECT imaging in various diseases that all in common have Parkinson symptoms (referred to as parkinsonism) which besides Parkinson’s Disease include: Atypical Parkinson’s Disease (Corticobasal Degeneration, Multisystemic Atrophy, Progressive supranuclear Paresis), Lewy Body Dementia, Normal Pressure Hydrocephalus spinocerebellar ataxia 3 and also differential diagnoses to the above: essential tremor, depression, dystonia and Alzheimer’s disease. So far my publications have primarily been on methodological issues for SPECT imaging on the dopamine transporter with the radioligand [123I]PE2I.

SPECT imaging in functional neurosurgery: normal pressure hydrocephalus, epilepsy and Parkinson’s disease.

Biography

2008 -	PhD Student, research fellow at the Neurobiology Research Unit
2002 - 2008	Pregraduate research student at the Neurobiology Research Unit
2006 - 2008	Internship, Region Zealand (Region Sjælland )
2006	MD Copenhagen University
2003	Junior year research student at the Neurobiology Research Unit

Publications

Publications:

Pinborg LH, Ziebell M, Frokjaer VG, de Nijs R, Svarer C, Haugbol S, Yndgaard S, Knudsen GM: Quantification of 123I-PE2I Binding to Dopamine Transporter with SPECT After Bolus and Bolus/Infusion. J Nucl Med. 2005 Jul;46(7):1119-1127.
Vogel A, Hasselbalch G S, Gade A, Ziebell M, Waldemar G: Cognitive and neuroanatomical correlates for anosognosia in Mild Cognitive Impairment and Alzheimer’s disease. Int J Geriatric Psychiatry 2005; 20: 238-246.
Ziebell M, Pinborg LH, Nijs R, Svarer C, Knudsen GM: Reproducibility of [123I]PE2I Binding to Dopamine Transporters with SPECT following bolus/infusion. Eur J Nucl Med Mol Imaging. 2007 Jan;34(1):101-9.
Pinborg LH, Videbaek C, Ziebell M, Mackeprang T, Friberg L, Rasmussen H, Knudsen GM, Glenthoj B: [123I]Epidepride binding to cerebellar dopamine D2/D3 receptors is displaceable: implications for the use of cerebellum as a reference region. Neuroimage. 2007 Feb 15;34(4):1450-3.
Ziebell M, Korbo L, Hasselbalch G S: Lewi Body-demens. Accepted September 2009 UFL.
Ziebell M, Pinborg LH, Thomsen G, de Nijs R, Svarer C, Wagner A, and Knudsen GM: MR guided region of interest delineation is comparable to manual derived delineations in dopamine transporter SPECT quantification in patients: A reproducibility study. Accepted March 2010 JNMT.

Conferences:

2004 - NeuroReceptor Mapping 2004 15-17 July, Vancouver, Canada (Poster presentation)
2006 - Society of Nuclear Medicine 3-7 June, San Diego USA (Oral presentation)
2006 - NeuroReceptor Mapping 2006 6-8 July, Copenhagen, Rigshospitalet (Poster presentation)
2008 - European Association of Nuclear Medicine 11-15 October, München (Poster presentation)
2009 - European Association of Nuclear Medicine 10-14 October, Barcelona (Oral presentation)

Boards

2009 - Young Scientist on Rigshospitalet (Foreningen af Yngre Forskere på Rigshospitalet)
2009 - Research committee of Rigshospitalet (Rigshospitalets Forskningsudvalg)

Society

2010 - Member of The Movement Disorder Society
2008 - Member of The Danish Society of Neurosurgery

Awards

2003 - Scholarship Copenhagen University (120.000)

Address

Neurobiology Research Unit
Rigshospitalet
Blegdamsvej 9
DK-2100 Copenhagen, Denmark
Phone: (+45) 3545 1468
Fax: (+45) 3545 6713
E-mail: morten.ziebell#nru.dk