Neurobiology Research Unit  
 
 larsp

Lars Hageman Pinborg

Associate professor, MD, DMSc

Scientific interests| Biography
Publications | Address

Scientific interests

Scientific interests are molecular imaging in neuropsychiatric disorders. Early studies have focused on developing methods for neuroreceptor imaging feasible in a clinical setting with a special interest in the bolus-infusion approach. Methods have been applied to the study of a variety of neuropsychiatric disorders including dementia, movement disorders and schizophrenia. Current research focus on molecular imaging in patients with epilepsy using PET, SPECT and MRI.

 

Biography

2009 -   Associate Professor, University of Copenhagen, Faculty of Health Sciences 
2009  Doctor of Medical Science (DMSc), University of Copenhagen, Faculty of Health Sciences 
2009 -  Part time research position at NRU financed by The Free Research Council | Health and Disease 
2008 -  Member of the Board of the Danish Neurological Society
2008 - Senior Hospital Physician, The Epilepsy Clinic, The Neuroscience Centre, Rigshospitalet, Copenhagen
2000 - 2004 Research Assistant, Neurobiology Research Unit
1996 - 2007 Basic medical training and specialist training in Neurology
1996 Medical Graduate (MD), University of Copenhagen, Faculty of Health Sciences

Publications

Total publications in peer-reviewed journals: 30

  1. Hasselbalch SG, Knudsen GM, Jakobsen J, Hageman LP, Holm S, Paulson OB (1994) Brain metabolism during short-term starvation in humans. J Cereb Blood Flow Metab 14(1):125-131
  2. Madsen PL, Hasselbalch SG, Hageman LP, Olsen KS, Bulow J, Holm S, Wildschirdtz G, Paulson OB, Lassen NA (1995) Persisting resetting of the cerebral oxygen/glucose uptake ratio by brain activation: Evidence obtained with the Kety-Schmidt tecnique. J Cereb Blood Flow Metab 15(3):485-491
  3. Hasselbalch SG, Knudsen GM, Jakobsen J, Hageman LP, Holm S, Paulson OB (1995) Blood-brain barrier permeability of glucose and ketone bodies during short-term starvation in humans. Am J Physiol 268(6):E1161-E1166
  4. Hasselbalch SG, Madsen PL, Pinborg Hageman L, Skovgaard Olsen K, Justesen N, Holm S, Paulson OB (1996) Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia. Am J Physiol 270(33): E746-E751
  5. Hasselbalch SG, Knudsen GM, Holm S, Hageman LP, Capaldo B, Paulson OB (1996) Transport of  D  glucose and 2 Fluorodeoxyglucose across the blood brain barrier in humans. J Cereb Blood Flow Metab 16:659-666
  6. Hasselbalch SG, Knudsen GM, Videbaek C, Pinborg LH, Schmidt JF, Holm S, Paulson OB (1999) No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans. Diabetes 48:1915-1921
  7. Pinborg LH, Videbæk C, Knudsen GM, Swahn CG, Halldin C, Friberg L, Paulson OB, Lassen NA. (2000) Dopamine D2 Receptor Quantification in Extrastriatal Brain Regions using [123I]Epidepride with Bolus/Infusion. Synapse 36: 322-329
  8. Pinborg LH, Videbæk C, Hasselbalch SG, Sørensen SA, Wagner A, Paulson OB, Knudsen GM (2001) Quantification of benzodiazepine receptor binding in Huntington’s disease using [123I]iomazenil and SPECT. J. Neurol. Neurosurg. Psychiatry 70:657-661
  9. Pinborg LH & Knudsen GM (2001) Kan man måle hjernens egen frisætning af neurotransmitter? Ugeskr Laeger 163:4596-4597
  10. Pinborg LH, Videbaek C, Svarer C, Yndgaard S, Paulson OB, Knudsen GM (2002) Quantification of [(123)I]PE2I binding to dopamine transporters with SPET. Eur J Nucl Med 29:623-31
  11. Pinborg LH, Adams KH, Svarer C, Holm S, Hasselbalch SG, Haugbol S, Madsen J, Knudsen GM (2003) Quantification of 5HT2A Receptors in the Human Brain using [18F]altanserin and the Bolus/Infusion Approach. J Cereb Blood Flow Metab 23:985-996
  12. Adams KH, Pinborg LH, Hasselbalch S, Svarer C, Mortensen EL, Holm S, Knudsen GM (2004) A database of [18F]-altanserin binding to 5-HT2A receptors in normal volunteers: normative data and relationship to physiological, and demographic variables. Neuroimage 21:1105-13
  13. Liptrot M, Adams KH, Martiny L, Pinborg LH, Lonsdale MN, Olsen NV, Holm S, Svarer C, Knudsen GM. (2004) Cluster analysis in kinetic modelling of the brain: a noninvasive alternative to arterial sampling. Neuroimage 21:483-93.
  14. Pinborg LH, Adams KH, Hasselbalch SG, Holm S, Yndgaard S, Svarer C, Knudsen GM (2004) [18F]altanserin binding to human 5HT2A receptors is unaltered after citalopram and pindolol challenge. J Cereb Blood Flow Metab 23:985-996
  15. Adams KH, Hansen ES, Pinborg LH, Hasselbalch S, Svarer C, Holm S, Bolwig TG, Knudsen GM (2005) Patients with Obessive-Compulsive Disorder have increased 5-HT2A receptor binding in the Caudate Nucleus. J Neuropsychopharmacology 8:391-401
  16. Svarer C, Madsen K, Hasselbalch SG, Pinborg LH, Haugbøl S, Frøkjær VG, Holm S, Paulson OB, Knudsen GM (2005) MR-based Automatic Delineation of Volumes of Interest in Human Brain PET-images using Probability Maps. Neuroimage 24:969-79
  17. Pinborg LH, Ziebell M, Frokjaer VG, de Nijs R, Svarer C, Haugbol S, Yndgaard S, Knudsen GM (2005) Quantification of [123I]PE2I Binding to Dopamine Transporters with SPECT following bolus and bolus/infusion. J Nucl Med 46:1119-27
  18. Kristiansen H, Elfving B, Plenge P, Pinborg LH, Gillings N, Knudsen GM (2005) Binding characteristics of the 5-HT2A receptor antagonists altanserin and MDL 100907. Synapse 58: 249-57
  19. Glenthoj BY, Mackeprang T, Svarer C, Rasmussen H, Pinborg LH, Friberg L, Baaré W,Hemmingsen R, Videbaek C (2006) Frontal Dopamine D(2/3) Receptor Binding in Drug-Naive First-Episode Schizophrenic Patients Correlates with Positive Psychotic Symptoms and Gender. Biol Psychiatry 60(6):621-9
  20. Ziebell M, Thomsen G, Knudsen GM, de Nijs R, Svarer C, Wagner A, Pinborg LH (2006) Reproducibility of [(123)I]PE2I binding to dopamine transporters with SPECT. Eur J Nucl Med Mol Imaging 34(1): 101-9
  21. Haugbøl S, Pinborg LH, Regeur L, Hansen ES, Bolwig TG, Nielsen FA, Svarer C,Skovgaard LT, Knudsen GM (2007) Cerebral 5-HT2A receptor binding is increased in patients with Tourette's syndrome. Int J Neuropsychopharmacol 10(2): 245-52
  22. Haugbøl S, Pinborg LH, Arfan HM, Frøkjaer VM, Madsen J, Dyrby TB, Svarer C,Knudsen GM (2007) Reproducibility and sample size estimations of 5-HT2A receptormeasurements with [18F]altanserin PET bolus plus infusion approach. Eur J Nucl Med Mol Imaging 34(6):910-5
  23. Hasselbalch SG, Hansen ES, Pinborg LH, Bolwig TG (2007) Reduced midbrain-pons serotonin transporter binding in patients with obsessive-compulsive-disorder. Acta Psychiatrica Scandinavia 115(5): 388-94
  24. Pinborg LH, Videbaek C, Ziebell M, Mackeprang T, Friberg L, Rasmussen H, Knudsen GM, Glenthøj BY (2007) [123I]Epidepride binding to cerebellar dopamine D2/D3 receptors  is displaceable: implications for the use of cerebellum as a reference region. Neuroimage 34(4): 1450-3
  25. Hasselbalch SG, Marner L, Pinborg LH, Holm S, Waldemar G, Knudsen GM.(2007) 5-HT2A receptor changes in mild cognitive impairment - correlation with cognition and neuropsychiatric symptoms. Accepted for publication in Neurobiology of Aging.
  26. Frokjaer VG, Mortensen EL, Nielsen FA, Haugbol S, Pinborg LH, Adams KH, Svarer C, Hasselbalch SG, Holm S, Paulson OB, Knudsen GM (2008) Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder. Biol Psychiatry 63(6): 569-76 
  27. Frokjaer VG, Pinborg LH, Madsen J, de Nijs R,Svarer C, Wagner A, Knudsen GM (2008) Evaluation of the Serotonin Transporter Ligand 123I-ADAM for SPECT studies on Humans. J Nucl Med 49(2): 247-54
  28. Erritzoe D, Rasmussen H, Kristiansen KT, Frokjaer VG, Haugbol S, Pinborg L,Baaré W, Svarer C, Madsen J, Lublin H, Knudsen GM, Glenthoj BY (2008) Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients.Neuropsychopharmacology 33(10):2435-41.
  29. Pinborg LH, Arfan H, Haugbol S, Kyvik KO, Hjelmbor JV, Svarer C, Frokjaer VG, Paulson OB, Holm S, Knudsen GM (2008) The 5-HT(2A) receptor binding pattern in the human brain is strongly genetically determined. Neuroimage 40(3): 1175-80 
  30. Rasmussen H, Erritzoe D, Andersen R, Ebdrup BH, Aggernaes B, Oranje B, Kalbitzer J, Madsen J, Pinborg LH, Baaré W, Svarer C, Knudsen GM, Glenthoj B (2010) Decreased frontal serotonin2A receptor binding in antipsychotic-naïve patients with first-episode schizophrenia. Arch Gen Psychiatry 67(1):9-16

Address

Neurobiology Research Unit
Rigshospitalet
Blegdamsvej 9
DK-2100 Copenhagen, Denmark
Phone: +45 3545 6712 
Fax: +45 3545 6713
E-mail: pinborg#nru.dk