Karine Madsen
MD, PhD Student
| |
Karine MadsenMD, PhD Student
|
I am interested in cognitive function,
serotonin receptor mapping and beta-amyloid deposits in patients
suffering from depression and Alzheimer''s diseasse. My PhD
project focuses on PET imaging of the cerebral 5-HT4 receptor in humans
in relation
to sex, aging and Alzheimer’s disease. The aim is to investigate
the human in
vivo 5-HT4 receptor binding with the novel PET radiotracer
[11C]SB207145 in
relation to sex, aging and Alzheimer's disease.
| 2007 - | PhD student at the Neurobiology Research Unit, Rigshospitalet |
| 2006 - 2007 | First year of specialisation as a neurologist at the Neurology and Rehabilitation Unit, Hillerød |
| 2004 - 2005 | Internship at the Department of
Medicine at Bispebjerg Hospital, Department of Abdominal Surgery at
Bispebjerg Hospital and as a general practitioner |
| 2004 | MD, University of Copenhagen |
| 1995 - 1997 | Studying mathematics and physics at the Faculty of Science, University of Copenhagen |
Adams KH, Pinborg LH, Svarer C, Hasselbalch SG, Haugbol S, Madsen K, Frokjaer V, Martiny L, Paulson OB, Knudsen GM: A database of [18F]-altanserin binding to 5-HT2A receptors in normal volunteers: normative data and relationship to physiological, and demographic variables. NeuroImage 2004;21:1105-13.
Svarer C, Madsen K, Hasselbalch SG, Pinborg LH, Haugbøl S, Frøkjær VG, Holm S, Paulson OB, Knudsen GM: MR-based automatic delineation of voules of interest in human brain PET images using probability maps. NeuroImage 2005;24:969-979.
Hasselbalch SG, Madsen K, Svarer C, Pinborg LH, Holm S, Paulson OB, Waldemar G, Knudsen GM: Reduced 5-HT2A receptor binding in patients with mild cognitive impairment. Neurobiol Aging, 2008;29(12):1830-8.
Frokjaer VG, Vinberg M, Erritzoe D, Svarer C, Baaré W,
Budtz-Joergensen E, Madsen K, Madsen J, Kessing LV, Knudsen GM: High familial
risk for mood disorder is associated with low dorsolateral prefrontal cortex
serotonin transporter binding. Neuroimage 2009;46(2):360-6
Marner L, Gillings N, Madsen K, Erritzoe D, Baaré WF, Svarer C, Hasselbalch SG, Knudsen GM: Brain Imaging of Serotonin 5-HT4 Receptors in Humans with [11C]SB207145-PET. Neuroimage 2010; 15;50(3):855-61
Marner L, Frokjaer VG, Kalbitzer J, Lehel S, Madsen K, Baaré WF, Knudsen GM, Hasselbalch SG. Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease. A combined [11C]DASB and [18F]altanserin-PET study. Neurobiol Agning. 2010 May 24. [Epub ahead of print]