Neurobiology Research Unit

Gerda Thomsen

Chief Medical Technologist

SPECT laboratory, Rigshospitalet

Scientific interests | Biography

Publications | Awards | Address

Scientific interests

Main clinical and scientific interest:

Functional brain 99mTc -HMPAO SPECT as a diagnostic tool for assessment of regional cerebral blood flow, particularly in dementia, cerebrovascular disease, and epilepsy.
Subtraction of interictal from ictal SPECT images with subsequent coregistration with MRI (SISCOM) as a useful diagnostic tool for identifying the epileptogenic region.
[123I]PE2I-SPECT as a diagnostic tool for assessment of imaging the dopamine transporter, particularly in Parkinson’s disease and uncertain parkinsonism.
The relationship between dopamine transporter (DAT) and BMI in normal and over-weight subjects with [123I]PE2I-SPECT
Correlation between smoking and DAT in healthy subjects using [123I]PE2I-SPECT

Biography

2001 - 2003	Rigshospitalet's Management Training
1990 -	Chief Medical Technologist and daily leader of the SPECT laboratory
1986 - 1990	Research Medical Technologist, Neurobiology Research Unit, Rigshospitalet
1979 - 1986	Medical Laboratory Technologist, Department of Clinical Chemistry, Sundby Hospital
1976 - 1979	Medical Laboratory Technologist trainee, Department of Clinical Chemistry, Sundby Hospital

Teaching
2007	Supervisor to medical technologist students at the Medical Laboratory Technology Programme, Copenhagen
2006	EANM '06; Annual Congres of the European Association of Nuclear Medicin, Athens, Education Technologists

Recents Presentations
2010	EANM'10; Oral presentation: "No correlation between body mass index and striatal dopamine transporter availability in healthy individuals, as measured with [123I]PE2I and [123I] FPCIT SPECT

Publications

Thomsen G. Billeddannelse af hjernen I. Hospitalslaboranten, nr. 1, 1993.
Thomsen G. Billeddannelse af hjernen II. Hospitalslaboranten, nr. 2, 1993.
Thomsen G. Billeddannelse af hjernens funktion. Hospitalslaboranten, nr. 15, 1994.
Thomsen G. Anvendelse af SPECT til måling af hjernens regionale blodgennemstrømning ved demenssygdom. Hospitalslaboranten, nr. 20, 1997.
Gruhn N, Larsen FS, Boesgaard S, Knudsen GM, Mortensen SA, Thomsen G, Aldershvile J. Cerebral blood flow in patients with chronic heart failure before and after heart transplantation. Stroke 2001;32:2530-3
Møller K, Strauss G, Thomsen G, Larsen FS, Skinhøj P, Knudsen GM. Cerebral blood flow, oxidative metabolism, and cerebrovascular carbondioxide reactivity in patients with bacterial meningitis. Acta Anaesthesiol Scand 2002;46:567-78
Thomsen G. SPECT-laboratoriet i Neurocentret. Optimering af organiseringen. Den projektorienterende ledelsesopgave, Rigshospitalets lederuddannelse (RL4) Dec. 2002
Thomsen. G. Funktionel billeddannelse af neuroreceptorer. Dbio nr.1, 2004
Knudsen GM, Karlsborg M, Thomsen G, Krabbe K, Regeur L, Nygaard T, Videbæk C, Werdelin L. Imaging of dopamine transporters and D2 receptors in patients with Parkinson’s disease and multiple system atrophy. European Journal of Nuclear Medicine and Molecular Imaging. July 2004
Ziebell M, Thomsen G, Knudsen GM,de Nijs R,Svarer C,Wagner A,Pinborg LH, Reproducibility of [(123)I]PE2I binding to dopamine transporters with SPECT.Eur J Nucl Med Mol Imaging, 34(1): 101-9 2007
Thomsen G, de Nijs R, Hogh-Rasmussen E, Svarer C, Frokjaer V, Knudsen GM. Required time delay from 99mTc -HMPAO injection to SPET data acquisition: Healthy subjects and patients with rCBF pattern. Eur J Nucl Med Mol Imaging. 35(12): 2212-2219 Dec 2008
Ziebell M, Pinborg L, Thomsen G, de Nijs R, Svarer C, Wagner A, Knudsen GM. MR guided ROI delineation is not superior to manual derived delineations in DAT SPECT images: A reproducibility study. J Nucl Med Tech. 38(2): 61-68 June 2010
de Nijs R, Holm S, Thomsen G, Ziebell M, Svarer C. Experimental determination of the weighting factor for the energy window subtraction based downscatter correction for I-123 in brain SPECT-studies. Journal of Medical Physics. May 2010
Svarer C, Thomsen G, Frøkjær V, Madsen K, Marner L, Erritzøe D, Hasselbalch S, Knudsen GM. An Automatic Method for Semi-Quantitative Assessment of Regional Cerebral Blood Flow Relative to a Database of Healthy Volunteers. Eur J Nucl Med Mol Imaging.( Submitted Jan 2010 )
Ziebell M, Holm-Hansen S, Thomsen G, Wagner A, Jensen P, Pinborg LH, Knudsen GM Serotonin transporters in dopamine transporter imaging: A head-to-head comparison of dopamine transporter SPECT radioligands [123I]FP-CIT and [123I]PE2I. J Nucl Med. Sept. 2010
Madsen J, Elfving B, Frøkjær VG, Kornum BR, Thomsen G, Martiny L, Knudsen GM. Synthesis and Biological Evaluation of 125I/123I-Labelled Analogues of Citalopram and Escitalopram as Potential Radioligands for Imaging of the Serotonin Transporter. Journal of Labelled Compounds and Radiopharmaceuticals. Sept. 2010

Awards

2006: The Development and Research Foundation of Medical Tehcnologists (Bioanalytikernes udviklings og forskningsfond): DKK 11.000 for covering expenses related to conference participation
2005: Medical technologist of the Year at Rigshospitalet (Årets bioanalytiker på Rigshospitalet)
2005: H:S (MVU funds): DKK 175.000 a year for i 2½ years: SPECT scan with Tc99m-SHMPAO. Scan time after injection validated in normal subjects and patients with memory disorders and dementia
2001: Brain Imaging Council Awards, Society of Nuclear Medicine, Third Place (oral presentation): SPECT-¹²³I-β-CIT as a diagnostic tool with Parkinson’s disease/Parkinson plus syndrome.
1992,2001, 2004, 2009: The Anniversary Foundation of Rigshospitalet (Rigshospitalets Jubilæumsfond) for covering expenses related to participation in international conferences.
1992: The Amersham grant for laboratory technicians (Amersham Laborant Legat) : DKK 25.000.

Address

SPECT Laboratory, N2081
Copenhagen University Hospital, Rigshospitalet
Blegdamsvej 9, DK-2100 Copenhagen, Denmark
Phone: +45 3545 2380/2381
Fax: +45 3545 6713
E-mail: gerda.thomsen#rh.regionh.dk