Publications

YEAR

2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001
2000 1999 1998 1997 1996

2011

Dissertations and PhD theses (1/4)
Madsen K. PET Imaging of Cerebral Serotonin 4 Receptors in Relation to Sex, Aging and Alzheimer’s Disease. København: Eget forlag 2011:1-54. Forsvaret d. 4.4.2011 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.
Palner M. Development & Evaluation of Monoaminergic Agonist PET Tracers. København:Eget forlag 2011:1-93. Forsvaret d. 11. marts 2011 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.
Ziebell M. Evaluation of the superselective radioligand [123I]PE2I for imaging of the dopamine transporter in SPECT. København:Eget forlag 2011:1-106. Forsvaret d. 18. marts 2011 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.
Lisbeth Marner, Communication among neurons. Quantitative measures in aging and disease. Disputats, København: Eget forlag 2011: 1-84. Forsvaret d. 16. September 2011 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet

Original publications in peer-reviewed journals

Aznar S, Knudsen GM. Depression and Alzheimer's Disease: Is stress the initiating factor in a common neuropathological cascade? J Alzheimers Dis. 2011;23(2):177-93.

Ansel L, Bentsen AH, Ancel C, Bolborea M, Klosen P, Mikkelsen JD, Simonneaux V. Peripheral kisspeptin reverses short photoperiod-induced gonadal regression in Syrian hamsters by promoting GNRH release. Reproduction. 2011;142(3):417-25

Castellano JM, Bentsen AH, Sánchez-Garrido MA, Ruiz-Pino F, Romero M, Garcia-Galiano D, Aguilar E, Pinilla L, Diéguez C, Mikkelsen JD, Tena-Sempere M. Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system. Endocrinology. 2011;152(9):3396-408.

Damsted SK, Born AP, Paulson OB, Uldall P. Exogenous glucocorticoids and adverse cerebral effects in children. Eur J Paediatr Neurol. 2011;15(6):465-77

El-Sayed M, Hofman-Bang J, Mikkelsen JD. Effect of brain derived neurotrophic factor on activity regulated cytoskeleton associated protein gene expression in primary frontal cortical neurons. Comparison with NMDA and AMPA. Eur J Pharmacol. 2011; 25;660(2-3):351-7.

Erritzoe D, Frokjaer VG, Holst KK, Christoffersen M, Johansen SS, Svarer C, Madsen J, Rasmussen PM, Ramsøy T, Jernigan TL, Knudsen GM. In Vivo Imaging of Cerebral Serotonin Transporter and Serotonin2A Receptor Binding in 3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") and Hallucinogen Users. Arch Gen Psychiatry. 2011;68(6):562-76.

Ettrup A, Kornum B, Weikop P, Knudsen GM. An approach for serotonin depletion in pigs: Effects on serotonin receptor binding. Synapse 2011;65(2):136-45

Ettrup A, Hansen M, Santini MA, Paine J, Gillings N, Palner M, Lehel S, Herth MM, Madsen J, Kristensen J, Begtrup M, Knudsen GM. Radiosynthesis and in vivo evaluation of a series of substituted (11)C-phenethylamines as 5-HT (2A) agonist PET tracers. Eur J Nucl Med Mol Imaging. 2011;38(4):681-93.

Ettrup A, Mikkelsen JD, Lehel S, Madsen J, Nielsen EO, Timmermann DB, Peters D and KnudsenGM; [11C]NS14492 as a novel PET radioligand for imaging cerebral α7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements. J Nucl Med. 2011;52(9):1449-56.

Jennings KA, Licht CL, Bruce A, Lesch KP, Knudsen GM, Sharp T. Genetic variation in 5-hydroxytryptamine transporter expression causes adaptive changes in 5-HT4 receptor levels. The International Journal of Neuropsychopharmacology 2011;16:1-9.

Jensen MM, Lange SC, Thomsen MS, Hansen HH, Mikkelsen JD. The Pharmacological Effect of KCNQ (Kv7) Positive Modulators on Dopamine Release from Striatal Slices. Basic Clin Pharmacol Toxicol. 2011:339-42.

Jensen PS, Thomsen G, Ziebell M, deNijs, R, Svarer C, Malik U, Skouboe G, Knudsen GM. Validation of a Method for Accurate and Highly Reproducible Quantification of Brain Dopamine Transporter SPECT Studies. J. Nuclear Medicine and Technology2011;39(4):271-8.

Klein AB, Williamson R, Santini MA, Clemmensen C, Ettrup A, Rios M, Knudsen GM, Aznar S. Blood BDNF concentrations reflect brain tissue BDNF levels across species. Int J Neuropsychopharmacol. (2011), 14, 347–353.

Koefoed P, Woldbye DPD, Hansen TO, Eplov LF,Christiansen SH, Mors O,Kessing LV, Werge T, Kaipio K, Pesonen U, Fahmy T, Mellerup E, Jakobsen KD, Hansen ES, Knudsen GM, Bukh JD, Bock C, Lindberg C, Kristensen AS, Dam H, Nordentoft M, Als TD, Wang AG, Gether U, Rehfeld JF, Bolwig TG Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression. Acta Neuropsychiatrica [Epub ahead of print].

Kornum BR, Knudsen GM. Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research. Neurosci Biobehav Rev 2011;35(3):437-51

Kupers R, Frokjaer V, Erritzoe D, Naert A, Budtz-Joergensen E, Nielsen FA, Kehlet H, Knudsen GM. Serotonin transporter binding in the hypothalamus correlates negatively with tonic heat pain ratings in healthy subjects: a [11C]DASB PET study. Neuroimage 2011;54(2):1336-43

Liu X, Cannon DM, Akula N, Moya PR, Knudsen GM, Arentzen TE, Steele J, Laje G, Drevets WC, McMahon FJ. A non-synonymous polymorphism in galactose mutarotase (GALM) is associated with serotonin transporter binding potential in the human thalamus: results of a genome-wide association study. Molecular Psychiatry 2011; 16, 584–5

Lou AR, Madsen KH, Paulson OB, Julian HO, Prause JU, Siebner HR, Kjaer TW. Monocular Visual Deprivation Suppresses Excitability in Adult Human Visual Cortex. Cereb Cortex. 2011:2876-82.

Lund H, Jønsson A, Andresen J, Rostrup E, Paulson OB, Sørensen PS. Cognitive deficits in multiple sclerosis: correlations with T2 changes in normal appearing brain tissue. Acta Neurol Scand. 2011 Jul 27. [Epub ahead of print]

Madsen J, Elfving B, Frøkjær VG, Kornum BR, Thomsen G, Martiny L, Knudsen GM. Synthesis and Biological Evaluation of 125I/123I-Labelled Analogues of Citalopram and Escitalopram as Potential Radioligands for Imaging of the Serotonin Transporter. J. Label Compd. Radiopharm 2011, 54 185–190

Madsen K, Haahr M, Marner L, Keller SH, Baaré W, Svarer C, Hasselbalch SG, Knudsen GM. Age and Sex Effects on 5-HT(4) Receptors in the Human Brain – A [11C]SB207145 PET Study. Journal of Cerebral Blood Flow & Metabolism 2011;31(6):1475-81

Madsen K, Erritzoe D, Mortensen EL, Gade A, Madsen J, Baaré W, Knudsen GM, Hasselbalch SG. Cognitive Function is Related to Fronto-striatal Serotonin Transporter Levels - A Brain PET Study in Young Healthy Subjects. Psychopharmacology (Berl). 2011;213(2-3):573-81.

Madsen K, Neumann WJ, Holst K, Marner L, Haarh MT, Lehel S, Knudsen GM, Hasselbalch SG. Cerebral Serotonin 4 receptors and Amyloid-β in Early Alzheimer’s Disease. J Alzheimers Dis. 2011; 1;26(3):457-66

Madsen K, Marner L, Haahr M, Gillings N, Knudsen GM. Mass Dose Effects and In Vivo Affinity in Brain PET Receptor Studies – A Study of Cerebral 5-HT4 Receptor Binding with [11C]SB207145. Nuclear medicine and biology 2011;38(8):1085-91

Madsen K, Hasselbalch BJ, Frederiksen KS, Haahr ME, Gade A, Law I, Price JC, Knudsen GM, Kessing LV, Hasselbalch SG. Lack of association between prior depressive episodes and cerebral [11C]PiB binding. Neurobiology of Aging. 2011 Dec 20 [Epub ahead of print]

Marner L, Frøkjær VG, Kalbitzer J, Lehel S, Madsen K, Baaré WF, Knudsen GM, Hasselbalch SG. Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease. A combined [11C]DASB and [18F]altanserin-PET study. Neurobiol Aging. 2010 May 24. [Epub ahead of print].

Marner L, Knudsen GM, Madsen K, Holm S, Baaré W, Hasselbalch SG. The reduction of Baseline Serotonin 2A Receptors in Mild Cognitive Impairment is stable at Two-year Follow-up. J Alzheimers Dis. 2011;23(3):453-9.

Palner M, Underwood MD, Kumar DJ, Arango V, Knudsen GM, Mann JJ, Parsey RV. Ex vivo evaluation of the serotonin 1A receptor partial agonist [(3)H]CUMI-101 in awake rats. Synapse. 2011;65(8):715-23

Palner M, Kjaerby C, Knudsen GM, Cummings P. Effects of unilateral 6-OHDA lesion on [3H]NPA binding in striatum ex vivo, and vulnerability to amphetamine-evoked dopamine release in rat. Neurochemistry International 58 (2011) 243–247

Paulson OB, Kanno I, Reivich M, Sokoloff L.History of International Society for Cerebral Blood Flow and Metabolism.J Cereb Blood Flow Metab. 2011 Dec 21. doi: 10.1038/jcbfm.2011.183. [Epub ahead of print]

Paterson L, Kornum B, Nutt D, Pike V, Knudsen GM 5-HT radioligands for human brain imaging with PET and SPECT. Medical research reviews [Epub ahead of print].

Ramsøy TZ, Liptrot MG, Skimminge A, Lund TE, Sidaros K, Christensen MS, Baaré W, Paulson OB, Jernigan TL, Siebner HR. Healthy aging attenuates task-related specialization in the human medial temporal lobe. Neurobiol Aging. 2011 Nov 2. [Epub ahead of print]

Rasmussen H, Ebdrup BH, Erritzoe D, Aggernaes B, Oranje B, Kalbitzer J, Pinborg LH, Baaré WF, Svarer C, Lublin H, Knudsen GM, Glenthoj B. Serotonin2A receptor blockade and clinical effect in first-episode schizophrenia patients treated with quetiapine. Psychopharmacology (Berl). 2011;213(2-3):583-92.

Ryberg C, Rostrup E, Paulson OB, Barkhof F, Scheltens P, van Straaten EC, van der Flier WM, Fazekas F, Schmidt R, Ferro JM, Baezner H, Erkinjuntti T, Jokinen H, Wahlund LO, Poggesi A, Pantoni L, Inzitari D, Waldemar G. Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: A 3-year follow-up of the LADIS study cohort. J Neurol Sci. 2011 Aug 15;307(1-2):100-105

Salem LC, Hejl AM, Garde E, Leffers AM, Paulson OB, Waldemar G. White matter hyperintensities and prepulse inhibition in a mixed elderly population. Psychiatry Res. 2011 30;194(3):314-8

Santini MA, Klein AB, El-Sayed M, Ratner C, Knudsen GM, Mikkelsen JD, Aznar S. Novelty-induced activity-regulated cytoskeletal-associated protein (arc) expression in frontal cortex requires Serotonin 2A receptor activation. Neuroscience 2011, 8;190:251-7.

Söderman A, Mikkelsen JD, West MJ, Christensen DZ, Jensen MS. Activation of nicotinic α(7) acetylcholine receptor enhances long term potentation in wild type mice but not in APPswe/PS1ΔE9 mice. Neurosci Lett 2011;487(3):325-9

Thomsen MS, Mikkelsen JD. The α7 nicotinic acetylcholine receptor complex: one, two or multiple drug targets? Current Drug Targets (accepted April 2011)

Thomsen MS, Weyn A, Mikkelsen JD, “Hippocampal α7 Nicotinic Acetylcholine Receptor Levels in Patients with Schizophrenia, Bipolar Disorder, or Major Depressive Disorder”. Bipolar Disorders 2011;13(7-8):701-7

Thomsen MS, El-Sayed M, Mikkelsen JD. Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats.PLoS One. 2011; 6(11) :e27014.

Vestergaard M, Madsen KS, Baaré WF, Skimminge A, Ejersbo LR, Ramsøy TZ, Gerlach C, Akeson P, Paulson OB, Jernigan TL. White Matter Microstructure in Superior Longitudinal Fasciculus Associated with Spatial Working Memory Performance in Children. J Cogn Neurosci. 2011;23(9):2135-46.

Williams WP 3rd, Jarjisian SG, Mikkelsen JD, Kriegsfeld LJ. Circadian control of kisspeptin and a gated GnRH response mediate the preovulatory luteinizing hormone surge. Endocrinology. 2011 Feb;152(2):595-606.

Ziebell M, Khalid U, Klein AB, Aznar S, Thomsen G, Jensen P, Knudsen GM. Striatal dopamine transporter binding correlates with serum BDNF levels in patients with striatal dopaminergic neurodegeneration. Neurobiol Aging 2011 428.e1-428.e5.

Ziebell M, Andersen BB, Thomsen G, Pinborg LH, Karlsborg M, Hasselbalch SG,Knudsen GM. Predictive value of dopamine transporter SPECT imaging with [123I]PE2I in patients with subtle parkinsonian symptoms. European Journal of Nuclear Medicine and Molecular Imaging 2011 Nov 18. [Epub ahead of print]

2010

Dissertations and PhD theses

de Nijs R. Corrections in clinical Magnetic Resonance Spectroscopy and SPECT: Motion correction in MR spectroscopy, Downscatter correction in SPECT. Forsvaret 2. marts 2010 ved Danmarks Tekniske Universitet, Institut for Informatik og Matematisk Modellering.

Ettrup, A. Serotonin receptor studies in the pig brain: pharmacological intervention and positron emission tomography tracer development. København:Eget Forlag 2010:1-52. Forsvaret d. 15. oktober 2010 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Klein AB. Brain-Derived Neurotrophic Factor (BDNF): Interactions with the serotonergic system and its potential as a biomarker in neurological and neuropsychiatric diseases. København:Eget forlag 2010:1-62. Forsvaret d. 17. september 2010 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Original publications in peer-reviewed journals
Ansel L, Bolborea M, Bentsen AH, Klosen P, Mikkelsen JD, Simonneaux V. Differential regulation of kiss1 expression by melatonin and gonadal hormones in male and female Syrian hamsters. J Biol Rhythms. 2010;25(2):81-91.

Axel AM, Mikkelsen JD, Hansen HH. Tesofensine, a Novel Triple Monoamine Reuptake Inhibitor, Induces Appetite Suppression by Indirect Stimulation of alpha(1) Adrenoceptor and Dopamine D(1) Receptor Pathways in the Diet-Induced Obese Rat. Neuropsychopharmacology 2010;35(7):1464-76.

Aznar S, Klein AB, Santini MA, Knudsen GM, Henn F, Gass P, Vollmayr B. Aging and depression vulnerability interaction results in decreased serotonin innervation associated with reduced BDNF levels in hippocampus of rats bred for learned helplessness. Synapse 2010;64(7):561-565.

Baaré WF, Vinberg M, Knudsen GM, Paulson OB, Langkilde AR, Jernigan TL, Kessing LV. Hippocampal volume changes in healthy subjects at risk of unipolar depression. J Psychiatr Res 2010;44(10):655-662.

Bentsen AH, Ansel L, Simonneaux V, Tena-Sempere M, Juul A, Mikkelsen JD. Maturation of kisspeptinergic neurons coincides with puberty onset in male rats. Peptides 2010;31(2):275-83.

Benveniste H, Fowler JS, Rooney WD, Scharf BA, Backus WW, Izrailtyan I, Knudsen GM, Hasselbalch SG, Volkow ND. Cocaine is Pharmacologically Active in the Non-Human Primate Fetal brain. Proc Natl Acad Sci U S A 2010;107(4):1582-7.

Castellano JM, Bentsen AH, Romero M, Pineda R, Ruiz-Pino F, Garcia-Galiano D, Sanchez-Garrido MA, Pinilla L, Mikkelsen JD, Tena-Sempere M. Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects. Am J Physiol Endocrinol Metab 2010;299(1):E54-61.

Christensen DZ, Mikkelsen JD, Hansen HH, Thomsen MS. Repeated administration of α7 nicotinic acetylcholine receptor (nAChR) agonists, but not positive allosteric modulators, increases α7 nAChR levels in the brain. J Neurochem 2010;114(4):1205-16.

Ebdrup BH, Glenthøj B, Rasmussen H, Aggernaes B, Langkilde AR, Paulson OB, Lublin H, Skimminge A, Baaré W. Hippocampal and caudate volume reductions in antipsychotic-naive first-episode schizophrenia. J Psychiatry Neurosci 2010;35(2):95-104.

Erritzøe D, Frøkjær VG, Haahr MT, Kalbitzer J, Svarer C, Holst KK, Hansen DL, Jernigan T, Lehel S. Cerebral serotonin transporter binding is inversely related to body mass index. Neuroimage 2010;1;52(1):284-9.

Erritzøe D, Holst K, Frøkjær VG, Licht CL, Kalbitzer J, Nielsen FA, Svarer C, Madsen J, Knudsen G. A Nonlinear Relationship between Cerebral Serotonin Transporter and 5-HT2A Receptor Binding: An In Vivo Molecular Imaging Study in Humans. J Neurosci 2010;30(9):3391-7.

Ettrup A, Palner M, Gillings N, Santini MA, Hansen M, Kornum BR, Rasmussen LK, Någren K, Madsen J, Begtrup M, Knudsen GM. Radiosynthesis and evaluation of [11C]Cimbi-5 as a 5-HT2A receptor agonist radioligand for positron emission tomography. Journal of Nuclear Medicine. 2010;51(11):1763-7

Frøkjær VG, Erritzøe D, Juul A, Nielsen FA, Holst K, Svarer C, Madsen J, Paulson OB, Knudsen GM. Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding. Psychoneuroendocrinology 2010;35(9):1311-2.

Frøkjær VG, Vinberg M, Erritzøe D, Baaré W, Holst KK, Mortensen EL, Arfan H, Madsen J, Jernigan TL, Kessing LV, Knudsen GM. Familial risk for mood disorder and the personality risk factor, neuroticism, interact in their association with frontolimbic serotonin 2A receptor binding. Neuropsychopharmacology 2010;35(5):1129-37.

Hansen HH, Hansen G, Tang-Christensen M, Larsen PJ, Axel AM, Raben A, Mikkelsen JD. The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: Comparison to sibutramine and rimonabant. Eur J Pharmacol 2010;636(1-3):88-95.

Holm P, Ettrup A, Klein AB, Santini MA, El-Sayed M, Elvang AB, Stensbøl TB, Mikkelsen JD, Knudsen GM, Aznar S. Plaque deposition dependent decrease in 5-HT_2A serotonin receptor in APP**swe/PS1dE9 amyloid overexpressing mice. J Alzheimers Dis 2010;1;20(4):1201-13

Kalbitzer J, Erritzøe D, Holst KK, Nielsen FA, Marner L, Lehel S, Arentzen T, Jernigan TL, Knudsen GM. Seasonal changes in brain serotonin transporter binding in short 5-HTTLPR-allele carriers but not in long-allele homozygotes. Biol Psych 2010;67(11):1033-9.

Kelsen J, Larsen MH, Sørensen JC, Møller A, Frøkiær J, Nielsen S, Nyengaard JR, Mikkelsen JD, Ronn LC. Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools. Exp Transl Stroke Med 2010;6;2:8.

Kiss A, Bundzikova J, Pirnik Z, Mikkelsen JD. Different antipsychotics elicit different effects on magnocellular oxytocinergic and vasopressinergic neurons as revealed by Fos immunohistochemistry. J Neurosci Res 2010;88(3):677-85.

Klein AB, Trajkovska V, Erritzøe D, Haugbøl S, Madsen J, Baaré W, Aznar S, Knudsen GM. Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. J Cereb Blood Flow Metab 2010 Nov;30(11):e1-7

Klein AB, Santini M, Aznar S, Knudsen GM, Rios M. Changes in 5-HT(2A)-mediated behavior and 5-HT(2A)- and 5-HT(1A) receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice. Neuroscience 2010;169(3):1007-1016.

Koefoed P, Woldby DPD, Hansen TO, Hansen ES, Knudsen GM, Bolwig TG, Rehfeld JF. Gene variations in the cholecystokinin system in patients with panic disorder. Psychiatr Genet 2010;20(2):59-64.

Kornum BR, Stott SR, Mattsson B, Wismann L, Ettrup A, Hermening S, Knudsen GM, Kirik D. Adeno-associated viral vector serotypes 1 and 5 targeted to the neonatal rat and pig striatum induce widespread transgene expression in the forebrain. Exp Neurol 2010;222:70-85

Kramer V, Herth MM, Santini MA, Palner M, Knudsen GM, Rösch F. Structural combination of established 5-HT2A receptor ligands: New aspects of binding mode. Chem Biol Drug Des. 2010 Oct;76(4):361-6.

Kupers R, Chebat DR, Madsen KH, Paulson OB, Ptito M. Neural correlates of virtual route recognition in congenital blindness. Proc Natl Acad Sci U S A 2010;107(28):12716-21.

Licht CL, Kirkegaard L, Zueger M, Gass P, Aznar S, Knudsen GM. Changes in 5-HT4 receptor and 5-HT transporter binding in olfactory bulbectomized and glucocorticoid receptor heterozygous mice. Neurochem Int 2010;56(4):603-610.

Licht CL, Knudsen GM, Sharp T. Effects of the 5-HT4 receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels. Neuroscience Letters. 2010;476(2):58-61

Madsen KS, Baaré WF, Vestergaard M, Skimminge A, Ejersbo LR, Ramsøy TZ, Gerlach C, Akeson P, Paulson OB, Jernigan TL. Response inhibition is associated with white matter microstructure in children. Neuropsychologia 2010;48(4):854-62.

Marner L, Gillings N, Madsen K, Erritzøe D, Baaré WF, Svarer C, Hasselbalch SG, Knudsen GM. Brain Imaging of Serotonin 4 Receptors in Humans with [11C]SB207145-PET. NeuroImage 2010;50(3):855-61.

Mikkelsen JD, Thomsen MS, Hansen HH, Lichota J. Use of biomarkers in the discovery of novel anti-schizophrenia drugs. Drug Discov Today 2010;15(3-4):137-141.

Nielsen SB, Franzmann M, Basaiawmoit RV, Wimmer R, Mikkelsen JD, Otzen DE. beta-sheet aggregation of kisspeptin-10 is stimulated by heparin but inhibited by amphiphiles. Biopolymers. 2010;93(8):678-89.

Palner M, McCormick P, Gillings N, Rasmussen LK, Begtrup M, Wilson AA, Knudsen GM. Radiosynthesis and ex vivo evaluation of (R)-(-)-2-chloro-N-[1-11C-propyl]n-propylnorapomorphine. Nucl Med Biol 2010;37(1):35-40.

Palner M, McCormick P, Parkes J, Knudsen GM, Wilson AA. Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C]SKF 82957. Nuclear Medicine and Biology 2010;37(7):837-43

Paterson LM, Tyacke RJ, Nutt DJ, Knudsen GM. Measuring endogenous 5-HT release by emission tomography: promises and pitfalls. J Cereb Blood Flow Metab. 2010 Jul 28. 2010;30(10):1682-706

Paulson OB, Hasselbalch SG, Rostrup E, Knudsen GM, Pelligrino D. Cerebral blood flow response to functional activation. J Cerebral Blood Flow Metab 2010;30(1):2-14

Prabhakaran J, Majo JM, Milak MS, Kassir SA, Palner M, Savenkova L, Mali P, Arango V, Mann JJ, Parsey RV. Synthesis, in vitro and in vivo evaluation of [11C]MMTP: A potential PET ligand for mGluR1 receptors. Bioorganic & Medicinal Chemistry Letters. 2010;15;20(12):3499-501.

Rasmussen H, Erritzøe D, Andersen R, Ebdrup B, Aggernaes B, Oranje B, Kalbitzer J, Madsen J, Pinborg L, Baaré W, Svarer C, Lublin H, Knudsen G, Glenthoj B. Decreased frontal serotonin2A receptor binding in antipsychotic-naïve patients with first-episode schizophrenia. Arch Gen Psychiatry 2010;67(1):9-16

Rasmussen H, Erritzøe D, Ebdrup B, Aggernaes B, Oranje B, Kalbitzer J, Madsen J, Pinborg L, Baaré W, Svarer C, Lublin H, Knudsen G, Glenthøj B. Serotonin2A receptor blockade and clinical effect in first-episode schizophrenia patients treated with quetiapine. Psychopharmacology. 2010;67(1):9-16

Thomsen MS, Hansen HH, Mikkelsen JD. Opposite effect of phenycyclidine on activity-regulated cytoskeleton-associated protein (arc) in juvenile and adult limbic rat brain regions. Neurochem Int 2010;56(2):270-5.

Thomsen MS, Hansen HH, Timmerman DB, Mikkelsen JD. Cognitive improvement by activation of alpha7 nicotinic acetylcholine receptors: from animal models to human pathophysiology. Curr Pharm Des 2010;16(3):323-43.

Thomsen MS, Hay-Schymidt A, Hansen HH, Mikkelsen JD. Distinct neural pathways mediate alpha7 nicotinic acetylcholine receptor-dependent activation of the forebrain. Cereb Cortex 2010;20(9):2092-102.

Thomsen MS, Hansen HH, Mikkelsen JD. Alpha 7 nicotinic receptor agonism mitigates phencyclidine-induced changes in synaptophysin and Arc gene expression in the mouse prefrontal cortex. Neurochemistry International, 2010;57(7):756-61.

Vinberg M, Frøkjær VG, Kessing LV. Coping styles in healthy individuals at risk of affective disorder. J Nerv Ment Dis 2010;198(1):39-44

Vrang N, Meyre D, Froguel P, Jelsing J, Tang-Christensen M, Vatin V, Mikkelsen JD, Thirstrup K, Larsen LK, Cullberg KB, Fahrenkrug J, Jacobson P, Sjöström L, Carlsson LM, Liu Y, Liu X, Deng HW,
Larsen PJ. The imprinted gene neuronatin is regulated by metabolic status and associated with obesity. Obesity (Silver Spring) 2010;18(7):1289-96.

Wellendorph P, Høg S, Sabbatini P, Pedersen MH, Martiny L, Knudsen GM, Frølund B, Clausen RP, Bräuner-Osborne H. N Novel radioiodinated GHB analogues for radiolabeling and photolinking of high-affinity GHB binding sites. J Pharmacol Exp Ther. 2010;335(2):458-64.

Ziebell M, Pinborg LH, Thomsen G, de Nijs R, Svarer C, Wagner A, Knudsen GM. MRI-guided region-of-interest delineation is comparable to manual delineation in dopamine transporter SPECT quantification in patients: a reproducibility study. J Nucl Med Technol 2010;38(2):61-8

Ziebell M, Korbo L, Hasselbalch SG. [Lewy body dementia]. Ugeskr Laeger. 2010;31;172(22):1675-8.

2009

Dissertations and PhD theses (1 / 6)
Erritzoe D. PhD-afhandling: In vivo serotonergic markers in overweight and schizophrenic human subjects. København: Eget forlag 2009:1-74. Forsvaret d. 17. april 2009 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Kalbitzer J. PhD-afhandling: The serotonin transporter and behavior: Gene environment interactions. København: Eget forlag 2009:1-120. Forsvaret d. 16. november 2009 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Kornum BR. PhD-afhandling: A pig model for studies of serotonergic mechanisms in memory disorders. København: Eget forlag 2009:1-70. Forsvaret d. 29. oktober 2009 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Licht CL. PhD-afhandling: Changes in the 5-HT4 receptor in animal models of depression and antidepressant treatment. København: Eget forlag 2009:1-61. Forsvaret d. 2. februar 2009 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Marner L. PhD-afhandling: Molecular brain imaging of the serotonin system: Reproducibility and evaluation of PET radiotracers. København: Eget forlag 2009:1-62. Forsvaret d. 13. marts 2009 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Pinborg LH. Disputats: Molecular imaging of receptors and transporters in humans using PET and SPECT: from models to methods and potentials to pitfalls. København: Eget forlag 2009:1-63. Forsvaret d. 4. juni 2009 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Rasmussen H. PhD-afhandling: Imaging serotonin 2A receptors in schizophrenia patients before and after first antipsychotic treatment. København: Eget forlag 2009:1-66. Forsvaret d. 18. september 2009 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Original publications in peer-reviewed journals (34)
Bendova Z, Sumova A, Mikkelsen JD. Circadian and developmental regulation of n-methyl-d-aspartate-receptor 1 mRNA splice variants and n-methyl-d-aspartate-receptor 3 subunit expression within the rat suprachiasmatic nucleus. Neuroscience 2009;159:599-609.

Bundzikova J, Pirnik Z, Zelena D, Mikkelsen JD, Kiss A. Alpha2-adrenergic impact on hypothalamic magnocellular oxytocinergic neurons in long evans and brattleboro rats: effects of agonist and antagonists. Cell Mol Neurobiol 2009;29:1015-23.

Butini S, Gemma S, Campiani G, Franceschini S, Trotta F,Borriello M, Ceres N, Ros S, Coccone SS, Bernetti M, Angelis MD, Brindisi M, Nacci V, Fiorini I, Novellino E, Cagnotto A, Mennini T, Sandager-Nielsen K, Andreasen JT, Scheel-Krüger J, Mikkelsen JD, Fattorusso C. Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: Design, synthesis, and effects on behavior. J Med Chem 2009;52:151-169.

de Nijs R, Miranda MJ, Hansen LK, Hanson LG. Motion correction of single-voxel spectroscopy by independent component analysis applied to spectra from nonanesthetized pediatric subjects. Magn Reson Med 2009;62(5):1147-54.

Erritzoe D, Frøkjær V, Haugbøl S, Marner L, Svarer C, Holst K, Baare W, Rasmussen PM, Madsen J, Paulson OB, Knudsen GM. Brain serotonin 2A receptor binding: Relations to body mass index, tobacco and alcohol use. Neuroimage 2009;46:23-30.

Frøkjær V, Vinberg M, Erritzøe D, Svarer C, Baaré W, Budtz-Jørgensen E, Madsen K, Madsen J, Kessing LV, Knudsen GM. High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding. Neuroimage 2009;46:360-6.

Frøkjær VG, Erritzøe D, Madsen J, Paulson OB, Knudsen GM. Gender and the use of hormonal contraception in women are not associated with cerebral cortical serotonin 2A receptor binding. Neuroscience 2009;163:640-5.

Gerlach C. Category-specificity in visual object recognition. Cognition 2009;111:281-301.

Herth MM, Kramer V, Piel M, Palner M, Riss PJ, Knudsen GM, Rösch F. Synthesis and in vitro affinities of various MDL 100907 derivates as potential (18)F-radioligands for 5-HT(2A) receptor imaging with PET. Bioorg Med Chem 2009;17:2989-3002.

Jacobsen JP, Redrobe JP, Hansen HH, Petersen S, Bond CT, Adelman JP, Mikkelsen JD, Mirza NR. Selective cognitive deficits and reduced hippocampal brain-derived neurotrophic factor mRNA expression in small-conductance calcium-activated K+ channel deficient mice. Neuroscience 2009;163:73-81.

Kalbitzer J, Frokjaer VG, Erritzoe D, Svarer C, Cumming P, Nielsen FÅ, Hashemi SH, Baaré WF, Madsen J, Hasselbalch SG, Kringelbach ML, Mortensen EL, Knudsen GM. The personality trait openness is related to cerebral 5-HTT levels. Neuroimage 2009;45:280-5.

Kalbitzer J, Svarer C, Frokjaer VG, Erritzoe D, Baaré WF, Madsen J, Hasselbalch SG, Knudsen GM. A probabilistic approach to delineating functional brain regions. J Nucl Med Technology 2009;37:91-5.

Knorr U, Vinberg M, Klose M, Feldt-Rasmussen U, Hilsted L, Gade A, Haastrup E, Paulson OB, Wetterslev J, Gluud C, Gether U, Kessing L. Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus placebo on the combined dexamethasone-corticotrophine releasing hormone test and other potential endophenotypes in healthy first-degree relatives of persons with depression. Trials 2009;10:66.

Knudsen GM. Testing for radioligand sensitivity to endogenous neurotransmitter release. Eur J Nucl Med Mol Imaging 2009;36:472-4.

Kornum BR, Lind NM, Gillings N, Marner L, Andersen F, Knuden GM. Evaluation of the novel 5-HT4 receptor PET ligand [11C]SB207145 in the Göttingen minipig. J Cereb Blood Flow Metab 2009;29:186-96.

Kupers R, Frokjaer VG, Naert A, Christensen R, Budtz-Joergensen E, Kehlet H, Knudsen GM. A PET [18F]altanserin study of 5-HT2A receptor binding in the human brain and responses to painful heart stimulation. Neuroimage 2009;44:1001-7.

Kupers R, Schneider FCG, Christensen R, Naert A, Husted H, Paulson OB, Kehlet H. No evidence for generalized increased postoperative responsiveness to pain: A combined behavioral and serial functional magnetic resonance imaging study. Anesth Analg 2009;109:600-6.

Licht CL, Marcussen AB, Wegener G, Overstreet DH, Aznar S, Knudsen GM. The brain 5-HT4 receptor binding is downregulated in the Flinders Sensitive Line depression model and in response to paroxetine administration. J Neurochem 2009;109:1363-74.

Marner L, Gillings N, Comley RA, Baaré WFC, Rabiner EA, Wilson AA, Houlse S, Hasselbalch SG, Svarer C, Gunn RN, Laruelle M, Knudsen GM. Kinetic modelling of [11C]SB207145 binding to 5-HT4 receptors in the human brain in vivo. J Nucl Med 2009;50:900-8.

Marner L, Knudsen GM, Haugbøl S, Holm S, Baaré W, Hasselbalch SG. Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: An [18F]-altanserin PET study. Eur J Nucl Med Mol Imaging 2009;36:287-93.

Mikkelsen JD, Bentsen AH, Ansel L, Simonneaux V, Juul A. Comparison of the effects of peripherally administered kisspeptins. Regul Peptides 2009;152:95-100.

Mikkelsen JD, Simonneaux V. The neuroanatomy of the kisspeptin system in the mammalian brain. Peptides 2009;30:26-33.

Nielsen FA. Visualizing data mining results with the brede tools. Front Neuroinformatics 2009;3:26.1-12

Nielsen FA. Lost in localization: a solution with neuroinformatics 2.0?. Neuroimage 2009;48(1):11-3.

Nielsen TR, Kornum BR, Moustgaard A, Gade A, Lind NM, Knudsen GM. A novel spatial delayed non-match to sample (DNMS) task in the Göttingen minipig. Behav Brain Res 2009;196:93-8.

Ramsøy TZ, Liptrot MG, Skimminge A, Lund TE, Sidaros K, Christensen MS, Baaré W, Paulson OB, Jernigan TL. Regional activation of the human medial temporal lobe during intentional encoding of objects and positions. Neuroimage 2009;47:1863-72.

Revel FG, Masson-Pévet M, Pévet P, Mikkelsen JD, Simonneaux V. Melatonin controls seasonal breeding by a network of hypothalamic targets. Neuroendocrinology 2009;90(1):1-14.

Sidaros A, Skimminge A, Liptrot MG, Sidaros K, Engberg AaW, Herning M, Paulson OB, Jernigan TL, Rostrup E. Long-term global and regional brain volume changes following severe traumatic brain injury: A longitudinal study with clinical correlates. Neuroimage 2009;44:1-8.

Simonneaux V, Ansel L, Revel FG, Klosen P, Pévet P, Mikkelsen JD. Kisspeptin and the seasonal control of reproduction in hamsters. Peptides 2009:30:146-53.

Syvänen S, Lindhe Ö, Palner M, Kornum BR, Rahman O, Långström B, Knudsen GM, Hammarlund-Udenaes M. Species differences in blood-brain barrier transport of three PET radioligands with emphasis on P-glycoprotein transport. Drug Metab Dispos 2009;37:635-43.

Thomsen MS, Christensen DZ, Hansen HH, Redrobe J, Mikkelsen JD. Alpha7 nicotinic acetylcholine receptor activation prevents behavioral and molecular changes induced by repeated phencyclidine treatment. Neuropharmacology 2009:56:1001-9.

Trajkovska V, Kirkegaard L, Krey G, Marcussen AB, Thomsen MS, Chourbaji S, Brandwein C, Ridder S, Halldin C, Gass P, Knudsen GM, Aznar S. Activation of glucocorticoid receptors increases 5-HT2A receptor levels. Exp Neurol 2009;218:83-91.

Trajkovska V, Santini MA, Marcussen AB, Thomsen MS, Hansen HH, Mikkelsen JD, Arneberg L, Kokaia M, Knudsen GM, Aznar S. BDNF downregulates 5-HT2A receptor protein levels in hippocampal cultures. Neurochem Int 2009;55:697-702.

Vinberg M, Trajkovska V, Bennike B, Knorr U, Knudsen GM, Kessing LV. The BDNF Val66Met polymorphism: Relation to familiar risk of affective disorder, BDNF levels and salivary cortisol. Psychoneuroendocrinology 2009;34:1380-9.

Lærebøger, andre oversigtsartikler og ledere
Gade A, Knudsen GM. Metaboliske, endokrine og andre systemiske sygdomme. In: Gade A, Gerlach C, Starrfelt R, Pedersen PM. Klinisk neuropsykologi. København: Frydenlund 2009:371-82.

Andet (abstracts ikke medtaget)
Knudsen GM. Personlighed kan læses i hjernen. Brunch TV2 11.03.2009 http://www.lorry.dk/moduler/nyheder/showregvideo.asp?dato=11-03-2009&cID=5&vId=473428

Marner L. Molekylær billeddannelse af hjernens serotoninsystem. BestPractice 2009:6-7

Paulson OB. Mogens Møller: Mogens Fog. Boganmeldelse. Ugeskr Laeger 2009

Jensen CG. Carsten Reidies Bjarkham: Neuroanatomi. Boganmeldelse. Indput 2009

Bolwig TG, Brennum J, Fink-Jensen A, Hasselbalch SG, Juhler M, Kjær T, Knudsen GM, Paulson OB. Forskere, der bidrog til Videnskabsteater-forestilling: Vis mig din hjerne, og jeg skal sige dig, hvem du er. Videnskabsteatret, København. Opført 11. marts og april på Rigshospitalet samt 19. november 2009 på Panum Instituttet.

2008

Dissertations and PhD theses (1 / 2)
Dethloff T. PhD-afhandling: Identification of factors responsible for impairment of cerebral blood flow autoregulation in acute liver failure. København: Eget forlag 2008:1-138. Forsvaret d. 12. september 2008 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Frøkjær V. PhD-afhandling: Relating cerebral serotonin 2A receptor and serotonin transporter binding to personality and familial risk for mood disorder. København: Eget forlag 2008:1-57. Forsvaret d. 11. juni 2008 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Gerlach C. Disputats: Visual object recognition and category-specificity. København: Eget forlag 2008:1-83. Forsvaret d. 7. november 2008 ved Københavns Universitet, Det Samfundsvidenskabelige Fakultet.

Original publications in peer-reviewed journals (23)
Bundzikova J, Pirnik Z, Zelena D, Mikkelsen JD, Kiss A. Response of substances co-expressed in hypothalamic magnocellular neurons to osmotic challenges in normal and Brattleboro rats. Cell Mol Neurobiol 2008;28:1033-47.

Christensen R, Marcussen AB, Wörtwein G, Knudsen GM, Aznar S. Aβ(1-42)injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT2A levels. Exp Neurol 2008;210:164-71.

Dethloff TJ, Knudsen GM, Larsen FS. Cerebral blood flow autoregulation in experimental liver failure. J Cereb Blood Flow Metab 2008;28:916-26.

Dyrby TB, Rostrup E, Baaré WFC, van Straaten ECW, Barkhof F, Vrenken H, Ropele S, Schmidt R, Erkinjuntti T, Wahlund L-O, Pantoni L, Inzitari D, Paulson OB, Hansen LK, Waldemar G. Segmentation of age-related white matter changes in a clinical multi-centre study. Neuroimage 2008;41:335-45.

Erritzoe D, Rasmussen H, Kristiansen KT, Frokjaer VG, Haugbol S, Pinborg L, Baaré W, Svarer C, Madsen J, Lublin H. Knudsen GM, Glenthoj BY. Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients. Neuropsychopharmacol 2008;33:2435-41.

Frokjaer VG, Mortensen EL, Nielsen FA, Haugbol S, Pinborg LH, Adams KH, Svarer C, Hasselbalch SG, Holm S, Paulson OB, Knudsen GM. Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder. Biol Psychiatry 2008;63:569-76.

Frokjaer VG, Pinborg LH, Madsen J, de Nijs R, Svarer C, Wagner A, Knudsen GM. Evaluation of the serotonin transporter ligand 123I-ADAM for SPECT studies on Humans. J Nucl Med 2008;49:247-54.

Hale MW, Hay-Schmidt A, Mikkelsen JD, Poulsen B, Shekhar A, Lowry CA. Exposure to an open-field arena increase c-Fos expression in a distributed anxiety-related system projecting to the basolateral amygdaloid complex. Neuroscience 2008;155:659-72.

Hale MW, Hay-Schmidt A, Mikkelsen JD, Poulsen B, Bouwknecht JA, Evans AK, Stamper CE, Shekhar A, Lowry CA. Exposure to an open-field arena increase c-Fos expression in a subpopulation of neurons in the dorsal raphe nucleus, including neurons projecting to the basolateral amygdaloid complex. Neuroscience 2008;157:733-48.

Hansen HH, Waroux O, Seutin V, Jentsch TJ, Aznar S, Mikkelsen JD. Kv7 channels: Interaction with dopaminergic and serotonergic neurotransmission in the CNS. J Physiol 2008;586:1823-32.

Hasselbalch SG, Madsen K, Svarer C, Pinborg LH, Holm S, Paulson OB, Waldemar G, Knudsen GM. Reduced 5-HT2A receptor binding in patients with mild cognitive impairment. Neurobiol Aging 2008;29:1830-8.

Herth MM, Debus F, Piel M, Palner M, Knudsen GM, Lüddens H, Rösch F. Total synthesis and evaluation of [18F]MHMZ. Bioorg Med Chem Let 2008;18:1515-19.

Jacobsen JPR, Weikop P, Hansen HH, Mikkelsen JD, Redrobe JP, Holst D, Bond CT, Adelman JP, Christophersen P, Mirza NR. SK3 K+ channel-deficient mice have enhanced dopamine and serotonin release and altered emotional behaviors. Genes Brain Behav 2008;7:836-48.

Kalowska E, Rostrup E, Rosenbaum S, Petersen P, Paulson OB. Acute MRI changes in progressive ischemic stroke. Eur Neurol 2008;59:229-36.

Mikkelsen JD, Bundzikova J, Larsen MH, Hansen HH, Kiss A. GABA regulates the rat hypothalamic-pituitary-adrenocortical axis via different GABA-A receptor alpha-subtypes. Ann N Y Acad Sci 2008;1148:384-92.

Pedersen M, Brandt C, Knudsen GM, Østergaard C, Skinhøj P, Skovsted IC, Frimodt-Møller N, Møller K. The effect of S. Pneumoniae bacteremia on cerebral blood flow autoregulation in rats. J Cereb Blood Flow Metab 2008;28:126-34.

Pinborg LH, Arfan H, Haugbol S, Kyvik KO, Hjelmborg JvB, Svarer C, Frokjaer VG, Paulson OB, Holm S, Knudsen GM. The 5-HT2A receptor binding pattern in the human brain is strongly genetically determined. Neuroimage 2008;40:1175-80.

Ptito M, Schneider FCG, Paulson OB, Kupers R. Alterations of the visual pathways in congenital blindness. Exp Brain Res 2008;187:41-9.

Ryberg C, Rostrup E, Sjöstrand K, Paulson OB, Barkhoff F, Scheltens P, van Straaten EC, Fazekas F, Schmidt R, Erkinjuntti T, Wahlund LO, Basile AM, Pantoni L, Inzitari D, Waldemar G. White matter changes contribute to corpus callosum atrophy in the elderly: The LADIS Study. Am J Neuroradiol 2008;29:1498-1504.

Sidaros A, Engberg AaW, Sidaros K, Liptrot MG, Herning MG, Petersen P, Paulson OB, Jernigan TL, Rostrup E. Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: a longitudinal study. Brain 2008;131:559-72.

Søderman A, Thomsen MS, Hansen HH, Nielsen EØ, Jensen MS, West MJ, Mikkelsen JD. The nicotinic α7 acetylcholine receptor agonist ssr 180711 is unable to activate limbic neurons in mice overexpressing human amyloid-β1-42. Brain Res 2008;1227:240-7.

Thomsen G, de Nijs R, Hogh-Rasmussen E, Frokjaer V, Svarer C, Knudsen GM. Required time delay from 99mTc-HMPAO injection to SPECT data acquisition: healthy subjects and patients with rCBF pattern. Eur J Nucl Med Mol Imaging 2008;35:2212-19.

Trajkovska V, Vinberg M, Aznar S, Knudsen GM, Kessing LV. Whole blood BDNF levels in healthy twins discordant for affektive disorder: Association to life events and neuroticism. J Affect Disord 2008;108:165-9.

Lærebøger, andre oversigtsartikler og ledere
Paulson OB, Knudsen GM. Comments on point: Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Role of a rudimentary sympathetic nervous system on cerebral blood flow. J Appl Physiol 2008;105:1371-2.

Paulson OB. Heart and brain circulation in healthy men are differently affected by CO2. Acta Physiol 2008;193:203.
Strandgaard S, Sigurdsson ST. Last word on point: Counterpoint: Sympathetic nervous activity does/does not influence cerebral blood flow. J Appl Physiol 2008:105:1366-7.

2007

Dissertations and PhD theses (3 / 2)
Haugbøl S. PhD-afhandling: Imaging brain serotonin 2A receptors: Methodological and genetic aspects and involvement in Tourette’s syndrome. København: Eget forlag 2007:1-79. Forsvaret d. 2. februar 2007 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Law I. Disputats: Human brain mapping under increasing cognitive complexity using regional cerebral blood flow measurements and positron emission tomography. København: Lægeforeningens Forlag 2007:1-94. Forsvaret d. 31. august 2007 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Møller K. Disputats: Cerebral blood flow and metabolism in adults with acute bacterial meningitis. København: Eget forlag 2007:1-64. Forsvaret d. 24. august 2007 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Strauss GI. Disputats: The effect of hyperventilation upon cerebral blood flow and metabolism in patients with fulminant hepatic failure. København: Lægeforeningens Forlag 2007:1-45. Forsvaret d. 30. marts 2007 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Trajkovska V. PhD-afhandling: Brain-derived neurotrophic factor (BDNF) and glucocorticoids: Influence on serotonin 2A receptors and relation to major depression. København: Eget forlag 2007:1-64. Forsvaret d. 5. oktober 2007 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Original publications in peer-reviewed journals (16)
Balslev D, Cole J, Miall RC. Proprioception contributes to the sense of agency during visual observation of hand movements: evidence from temporal judgments of action. J Cogn Neurosci 2007;19:1535-41.

Christensen MS, Lundbye-Jensen J, Geertsen SS, Petersen TH, Paulson OB, Nielsen JB. Premotor cortex modulates somatosensory cortex during voluntary movements without proprioceptive feedback. Nat Neurosci 2007;10:417-9.

Dyrby TB, Sogaard LV, Parker GJ, Alexander DC, Lind NM, Baare WF, Hay-Schmidt A, Eriksen N, Pakkenberg B, Paulson OB, Jelsing J. Validation of in vitro probabilistic tractography. Neuroimage 2007;37:1267-77.

Elfving B, Madsen J, Knudsen GM. Neuroimaging of the serotonin reuptake site requires high affinity ligands. Synapse 2007;61:882-8.
Gerlach C. A review of functional imaging studies on category specificity. J Cogn Neuroscience 2007;19:296-314.

Hasselbalch SG, Hansen ES, Jacobsen TB, Pinborg LH, Lønborg JH, Bolwig TG. Reduced midbrain-pons serotonin transporter binding in patients with obsessive-compulsive disorder. Acta Psychiatr Scand 2007;115:388-94.

Haugbol S, Pinborg LH, Regeur L, Hansen ES, Bolwig TG, Nielsen FA, Svarer C, Skovgaard LT, Knudsen GM. Cerebral 5-HT2A receptor binding is increased in patients with Tourette's syndrome.
Int J Neuropsychopharmacol 2007 Apr;10(2):245-52.

Haugbøl S, Pinborg LH, Arfan HM, Frøkjær V, Madsen J, Dyrby TB, Svarer C, Knudsen GM. Reproducibility of 5-HT2A receptor measurements and sample size estimations with [18F]altanserin PET using a bolus/infusion approach. Eur J Nucl Med Mol Imaging 2007;34:910-5.

Kornum BR, Thygesen KS, Nielsen TR, Knudsen GM, Lind NM. The effect of the inter-phase interval in the spontaneous object recognition test for pigs. Behav Brain Res 2007;181:210-7.

Olling JD, Ulrichsen J, Haugbøl S, Glenthøj B, Hemmingsen R, Woldbye DP. Decreased gene expression of neuropeptide Y and its receptors in hippocampal regions during ethanol withdrawal in rats. Neurosci Lett 2007;424:160-4.

Pedersen M, Brandt CT, Knudsen GM, Ostergaard C, Skinhoj P, Frimodt-Moller N, Moller K. Cerebral blood flow autoregulation in early experimental S. pneumoniae meningitis. J Appl Physiol 2007;102(1):72-8.

Pinborg LH, Videbaek C, Ziebell M, Mackeprang T, Friberg L, Rasmussen H, Knudsen GM, Glenthoj BY. [123I]Epidepride binding to cerebellar dopamine D2/D3 receptors is displaceable: Implications for the use of cerebellum as a reference region. Neuroimage 2007;34:1450-3.

Rowe JB, Sakai K, Lund TE, Ramsøy T, Christensen MS, Baare WFC, Paulson OB, Passingham RE. Is the prefrontal cortex necessary for establishing cognitive sets? J Neuroscience 2007;27:13303-10.

Severino M, Pedersen AF, Trajkovska V, Christensen E, Lohals R, Veng LM, Knudsen GM, Aznar S. Selective immunolesion of cholinergic neurons leads to long-term changes in 5-HT2A receptor levels in hippocampus and frontal cortex. Neurosci Lett 2007;428:47-51.

Starrfelt R, Gerlach C. The visual what for area: Words and pictures in the left fusiform gyrus. Neuroimage 2007;35:334-42.

Trajkovska V, Marcussen AB, Vinberg M, Hartvig P, Aznar S, Knudsen GM. Measurements of brain-derived neurotrophic factor: Methodological aspects and demographical data. Brain Res Bull 2007;73:143-9.

Ziebell M, Thomsen G, Knudsen GM, de Nijs R, Svarer C, Wagner A, Pinborg LH. Reproducibility of [(123)I]PE2I binding to dopamine transporters with SPECT. Eur J Nucl Med Mol Imaging 2007;34:101-9.

Lærebøger, andre oversigtsartikler og ledere
Innis RB, Cunningham VJ, Delforge J, Fujita M, Gjedde A, Gunn RN, Holden J, Houle S, Huang S-C, Ichise M, Iida H, Ito H, Kimura Y, Koeppe RA, Knudsen GM, Knuuti J, Lammertsma AA, Laruelle M, Logan J, Maguire RP, Mintun MA, Morris ED, Parsey R, Price JC, Slifstein M, Sossi V, Suhara T, Votaw JR, Wong DF, Carson RE. Consensus nomenclature for in vivo imaging of reversibly-binding radioligands. J Cereb Blood Flow Metab, 2007:27;1533-9.

Knudsen GM. Emotioner og hjernens transmittersystemer. In: Jensen TW, Skov M, eds. Følelser og kognition. København: Museum Tusculanums Forlag, 2007:113-25.

Paulson OB, Balslev D, Gerlach C. Hvad er PET og fMRI? In: Jensen TW, Skov M, eds. Følelser og kognition. København: Museum Tusculanums Forlag, 2007:37-53.

Paulson OB, Parving HH. Niels A. Lassens banebrydende forskning. Ugeskr Laeger 2007;169:2899.

Ramsøy T, Balslev D, Paulson OB. Methods for observing the living brain. In: Baars BJ, Gage NM, eds. Cognition, brain and consciousness. Amsterdam: Academic Press, 2007:477-511.

Sigurdsson ST, Strandgaard S. Blood pressure lowering in acute ischaemic stroke: an update on the role of angiotensin receptor blockers. J Hypertens 2007;25:743-5.

Skov M, Stjernfelt F, Paulson OB. Language and the brain’s mental cinema. In: Grundtvig B, McLaughlin M, Petersen LW, eds. Image, eye and art in Calvino. London: Modern Humanities Research Association and Maney Publishing, 2007:185-99.

Strandgaard S, Paulson OB. Hypertension and brain. In: Anand MP, Nadkar MY, eds. Hypertension. India: IJCP Group of Publications, 2007;137-42.

Strandgaard S, Paulson OB. Management of hypertension with cerebrovascular disease. In: Anand MP, Nadkar MY, eds. Hypertension. India: IJCP Group of Publications, 2007;268-72.

2006

Dissertations and PhD theses (2)
Høgh-Rasmussen E. PhD-afhandling: Tomographic reconstruction using anatomy and regularization. København: Eget forlag 2006:1-184. Forsvaret d. 17. februar 2006 ved Danmarks Tekniske Universitet.

Søndergaard K. PhD-afhandling: Synthesis, binding studies and PET studies of 2-substituted apomorphines. København: HCØ Tryk 2006:1-88. Forsvaret d. 26. januar 2006 ved Danmarks Farmaceutiske Universitet

Original publications in peer-reviewed journals (14)
Andersen PB, Blinkenberg M, Lassen U, Kosteljanetz M, Wagner A, Poulsen HS, Sørensen PS, Paulson OB. A prospective PET study of patients with glioblastoma multiforme. Acta Neurol Scand 2006;116:412-8.

Balslev D, Nielsen FAa, Lund TE, Law I, Paulson OB. Similar brain networks for detecting visuo-motor and visuo-proprioceptive synchrony. Neuroimage 2006;31:308-12.

Frøkjær VG, Strauss GI, Mehlsen J, Knudsen GM, Rasmussen V, Larsen FS. Autonomic dysfunction and impaired cerebral autoregulation in cirrhosis. Clin Auton Res 2006;16:208-16.

Gerlach C, Law I, Paulson OB. Shape configuration and category-specificity. Neuropsychologia 2006;44:1247-60.

Glenthoj BY, Mackeprang T, Svarer C, Rasmussen H, Pinborg LH, Friberg L, Baaré W, Hemmingsen R, Videbaek C. Frontal dopamine D2/3 receptor binding in drug-naive first-episode schizophrenic patients correlates with positive psychotic symptoms and gender. Biol Psychiatry 2006;60:621-9.

Husum H, Aznar S, Høyer-Hansen S, Larsen MH, Mikkelsen JD, Møller A, Mathé AA, Wörtwein G. Exacerbated loss of cell survival, neuropeptide Y-immunoreactive (IR) cells, and serotonin-IR fiber lengths in the dorsal hippocampus of the aged flinders sensitive line “depressed” rat: Implications for the pathophysiology of depression? J Neuroscience Res 2006;84:1292-1302.

Kondziella D, Brenner E, Eyjolfsson EM, Markinhuhta KR, Carlsson ML, Sonnewald U. Glial-neuronal interactions are impaired in the schizophrenia model of repeated MK801 exposure. Neuropsychopharmacology 2006;31(9):1880-7.

Kornum BR, Weikop P, Møller A, Ronn LCB, Knudsen GM, Aznar S. Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus. Brain Research 2006;1073-1074:262-8.

Kornum BR, Licht CL, Weikop P, Knudsen GM, Aznar S. Central serotonin depletion affects rat brain areas differently: A qualitative and quantitative comparison between different treatment schemes. Neurosci Lett 2006;392:129-34.

Lindberg C, Koefoed P, Hansen ES, Bolwig TG, Rehfeld JF, Mellerup E, Jorgensen OS, Kessing LV, Werge T, Haugbol S, Wang AG, Woldbye DP. No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population. Acta Psychiatr Scand 2006;113:54-8.

Linde R, Hasselbalch SG, Topp S, Paulson OB, Madsen PL. Global cerebral blood flow and metabolism during acute hyperketonemia in the awake and anesthetized rat. J Cereb Blood Flow Metab 2006;26:170-80.

Mathiesen HK, Jonsson A, Tscherning T, Hanson LG, Andresen J, Blinkenberg M, Paulson OB, Sorensen PS. Correlation of global N-acetyl aspartate with cognitive impairment in multiple sclerosis. Arch Neurol 2006;63:533-6

Nielsen K, Rostrup E, Frederiksen JL, Knudsen S, Mathiesen HK, Hanson LG, Paulson OB. Magnetic resonance imaging at 3.0 Tesla detects more lesions in acute optic neuritis than at 1.5 Tesla. Invest Radiol 2006;41:76-82.

Nielsen K, Brask D, Knudsen GM, Aznar S. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse 2006;59:270-6.
Scheuer KH, Nielsen JE, Krabbe K, Paulson OB, Law I. Motor activation in SPG4 linked hereditary spastic paraplegia. J Neurol Sci 2006;244:31-9.

Lærebøger, andre oversigtsartikler og ledere
Hasselbalch SG, Knudsen GM. Imaging of neurotransmitter systems in dementia. In: Herholz K, Perani D, Morris C, eds. The Dementias. Early Diagnosis and Evaluation. New York: Taylor and Francis Group 2006:253-77.

2005

Dissertations and PhD theses (1)
Balslev D. Ph.d.-afhandling: Proprioception - an obstacle for motor control in conditions with a visuoproprioceptive conflict. København: Eget forlag 2005:1-73. Forsvaret d. 12. september 2005 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Original publications in peer-reviewed journals (21)
Adams KH, Hansen ES, Pinborg LH, Hasselbalch SG, Svarer C, Holm S, Bolwig TG, Knudsen GM. Patients with obsessive-compulsive disorder have increased 5-HT2A receptor binding in the caudate nuclei. Int J Neuropsychopharmacol 2005;8:391-401

Aznar S, Kostova V, Christiansen SH, Knudsen GM. Alpha7 nicotinic receptor subunit is present on serotonin neurons projecting to hippocampus and septum. Synapse 2005;55(3):196-200

Balslev D, Nielsen FÅ, Paulson OB, Law I. Right temporoparietal cortex activation during visuo-proprioceptive conflict. Cereb Cortex 2005;15:166-9.

Dethloff T, Knudsen GM, Hansen BA, Larsen FS. Effects of porta-systemic shunting and ammonia infusion on cerebral blood flow autoregulation in the rat. Neurocrit Care 2005;3(1):86-90.

Fenger MM, Gade A, Adams KH, Hansen ES, Bolwig TG, Knudsen GM. Cognitive deficits in obsessive-compulsive disorder on tests of frontal lobe functions. Nord J Psychiatry 2005;59:39-44.

Garde E, Lykke Mortensen E, Rostrup E, Paulson OB. Decline in intelligence is associated with progression in white matter hyperintensity volume. J Neurol Neurosurg Psychiatry 2005;76:1289-91.

Gerlach C, Marstrand L, Habekost T, Gade A. A case of impaired shape integration: Implications for models of visual object processing. Visual Cognition 2005;12(8):1409-43.

Jelsing J, Rostrup E, Markenroth K, Paulson OB, Gundersen HJG, Hemmingsen R, Pakkenberg B. Assessment of in vivo MR imaging compared to physical sections in vitro - A quantitative study of brain volumes using stereology. NeuroImage 2005;26:57-65.

Kristiansen H, Elfving B, Plenge P, Pinborg LH, Gillings N, Knudsen GM. Binding characteristics of the 5-HT2A receptor antagonists altanserin and MDL100907. Synapse 2005 Dec 15;58(4):249-57.

Mathiesen HK, Tscherning T, Sørensen PS, Larsson HBW, Rostrup E, Paulson OB, Hanson LG. Multi-slice echo-planar spectroscopic MR imaging provides both global and local metabolite measures in multiple sclerosis. Magn Reson Med 2005;53:750-9.

Nielsen FÅ, Balslev D, Hansen LK. Mining the posterior cingulate: Segregation between memory and pain components. Neuroimage 2005;27:520-32.

Pinborg LH, Ziebell M, Frøkjær VG, de Nijs R, Svarer C, Haugbøl S, Yndgaard S, Knudsen GM. Quantification of 123I-PE2I binding to dopamine transporter with SPECT after bolus and bolus/infusion. J Nucl Med 2005;46:1119-27.

Pryds A, Tønnesen J, Knudsen GM, Greisen G. Cerebral autoregulation in a rat pup model. Pediatr Res. 2005;57:294-8.

Rostrup E, Knudsen GM, Law I, Holm S, Larsson HB, Paulson OB. The relationship between cerebral blood flow and volume in humans. Neuroimage 2005;24:1-11

Rostrup E, Larsson HBW, Born AP, Knudsen GM, Paulson OB. Changes in BOLD and ADC weighted imaging in acute hypoxia during sea-level and altitude adapted states. Neuroimage 2005;28:947-55.

Scheuer KH, Nielsen JE, Krabbe K, Simonsen C, Koefoed P, Sorensen SA, Gade A, Paulson OB, Law I. Reduced regional cerebral blood flow in SPG4-linked hereditary spastic paraplegia. J Neurol Sci 2005;15;235:23-32.

Svarer C, Madsen K, Hasselbalch SG, Pinborg LH, Haugbøl S, Frøkjær VG, Holm S, Paulson OB, Knudsen GM. MR-based automatic delineation of volumes of interest in human brain PET-images using probability maps. NeuroImage 2005;24:969-79

Søndergaard K, Kristensen JL, Palner M, Gillings N, Knudsen GM, Roth BL, Begtrup M. Synthesis and binding studies of 2-arylapomorphines. Org Biomol Chem 2005;3(22):4077-81.

Tønnesen J, Pryds A, Larsen EH, Paulson OB, Hauerberg J, Knudsen GM. Laser Doppler flowmetry is valid for measurement of cerebral blood flow autoregulation lower limit in rats. J Exp Physiol 2005;90:349-55.

Søndergaard K, Kristensen JL, Gillings N, Begtrup M. Synthesis of (R)-(-)-2-fluoronorapomorphine - A precursor for the synthesis of (R)-(-)-2-fluoro-N[11C}propylnorapomorphine for evaluation as a dopamine D2 agonist ligand for PET investigations. Eur J Org Chem 2005;20:4428-33.

Vogel A, Hasselbalch SG, Gade A, Ziebell M, Waldemar G. Cognitive and functional neuroimaging correlates for anosognosia in Mild Cognitive Impairment and Alzheimer’s disease. Int J Geriatr Psychiatry 2005;20:238-46.

Lærebøger, andre oversigtsartikler og ledere
Knudsen GM, Paulson OB, Petersen P. Neurologiske sygdomme. I: Hansen NE, Haunsø S, de Muckadell OBS, eds. Medicinsk Kompendiums Lommebog, 3. udgave. København: Nyt Nordisk Forlag Arnold Busck A/S, 2005:526-68.

2004

Dissertations and PhD theses (2)
Adams KH. Ph.d.-afhandling 2004: The in vivo brain distribution of serotonin 5-HT2A receptors in healthy subjects and in patients with obsessive-compulsive disorder: a positron emission study with [18F]-altanserin.

Scheuer KH. Ph.d.-afhandling 2004: Assessment of cerebral involvement in SPG4 linked hereditary spastic paraplegia.

Original publications in peer-reviewed journals (17)
Adams KH, Pinborg LH, Svarer C, Hasselbalch SG, Holm S, Mortensen EL, Haugbøl S, Madsen K, Frokjaer V, Martiny L, Paulson OB, Knudsen GM: A database of [18F]-altanserin binding to 5-HT2A receptors in normal volunteers: normative data and relationship to physiological, and demographic variables. NeuroImage 2004;21:1105-13

Aznar S, Qian ZX, Knudsen GM. Non-serotonergic dorsal and median raphe projection on parvalbumin- and calbindin-containing neurons in hippocampus and septum. Neuroscience 2004;124(3):573-81.

Balslev D, Christensen LOD, Lee J-H, Law I, Paulson OB, Miall RC. Enhanced accuracy in novel mirror drawing after repetitive transcranial magnetic stimulation-induced proprioceptive deafferentation. J Neurosci 2004;24:9698-9702.

Cohen ER, Rostrup E Sidaros K Lund TE, PaulsonOB, Ugurbil K, Kim S-G. Hypercapnic normalization of BOLD fMRI: comparison across field strengths and pulse sequences. Neuroimage 2004;23:613-24.

Fumagalli M, Mosca F, Knudsen GM, Greisen G. Transient hyperoxia and residual cerebrovascular effects in the newborn rat. Pediatr Res 2004;55(3):380-4.

Fumagalli M, Mosca F, Knudsen GM, Greisen G. A newborn rat model for the study of cerebral hemodynamics by near-infrared spectroscopy and laser-Doppler flowmetry in the immature brain. Biol Neonate 2004;85(2):112-20.

Gerlach C, Law I, Paulson OB. Structural similarity and category-specificity: a refined account. Neuropsychol 2004;42:1543-53.

Humphreys GW, Kylingsbæk S, Watson DG, Olivers CNL, Law I, Paulson OB. Parieto-occipital areas involved in efficient filtering in search: A time course analysis of visual marking using behavioural and functional imaging procedures. Q J Exp Psychol A 2004;57:610-35.

Knudsen GM, Karlsborg M, Thomsen G, Krabbe K, Regeur L, Nygaard T, Videbæk C, Werdeling L. Imaging of dopamine transporters and D2 receptors in patients with Parkinsons disease and multiple system atrophy. Eur J Nuclear Med Mol Imaging 2004;12:1631-8.

Liptrot M, Adams KH, Martiny L, Pinborg LH, Lonsdale MN, Olsen NV, Holm S, Svarer C, Knudsen GM: Cluster analysis in kinetic modelling of the brain: a non-invasive alternative to arterial sampling. NeuroImage 2004;21:483-493.

Madsen J, Elfving B, Andersen K, Martiny L, Knudsen GM. Gas phase production of [11C]methyl iodide-d3. Synthesis and biological evaluation of S-[N-methyl-11C]citalopram and deuterated analogues. J Label Compd Radiopharm 2004;47:335-48.

Møller K, Qvist T, Tofteng F, Sahl C, Sønderkær S, Dethloff T, Knudsen GM, Larsen FS. Cerebral blood flow and metabolism during infusion of norepinephrine and propofol in patients with bacterial meningitis. Stroke 2004;35:1333-9.

Nielsen FA, Hansen LK, Balslev D. Mining for associations between text and brain activation in a functional neuroimaging database. Neuroinformatics 2004;4:369-80.

Nielsen JE, Johnsen B, Koefoed P, Scheuer KH, Grønbech-Jensen M, Law I, Krabbe K, Nørremølle A, Eiberg H, Søndergård H, Dam M, Rehfeld JF, Krarup C, Paulson OB, Hasholt L, Sørensen SA. Hereditary spastic paraplegia with cerebellar ataxia: a complex phenotype associated with a new SPG4 gene mutation. Eur J Neurol 2004;11:817-24.

Pinborg LH, Adams KH, Yndgaard S, Hasselbalch SG, Holm S, Kristiansen H, Paulson OB. Knudsen GM. [18F]altanserin binding to human 5HT2A receptors is unaltered after citalopram and pindolol challenge. J Cereb Blood Flow Metab 2004;24:1037-45.

Quarantelli M, Berkouk K, Prinster A, Landeau B, Svarer C, Balkay L, Alfano B, Brunetti A, Baron JC, Salvatore M. Integrated Software for the Analysis of Brain PET/SPECT Studies with Partial-Volume-Effect Correction. J Nucl Med 2004;45:192-201.

Sveen ML, Knudsen GM, Aznar S. No effect of MDMA (ecstasy) on cell death and 5-HT(2A) receptor density in organotypic rat hippocampal cultures. Neurosci Lett. 2004;362:6-9.

Lærebøger, andre oversigtsartikler og ledere
Eskesen V, Paulson OB. Bevidsthedssvækkelse og bevidstløshed. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:197-214.

Knudsen GM, Paulson OB. Hjernens fysiologi. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:239-54.

Knudsen GM, Sørensen PSS. Neurologiske manifestationer ved systemiske sygdomme. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. København: FADL’s Forlag. 4. udg. 2004:609-28.

Knudsen GM, Rostrup E, Hasselbalch SG. Quantitative PET for assessment of cerebral blood flow and glucose consumption under varying physiological conditions. Int Congress Series 2004;1265:189-200

Paulson OB. Mobiltelefoni - kan det påvirke blod-hjerne-barrieren? Ugeskr Læger 2004;13:1209-11.

Paulson OB, Boysen G, Krarup C, Knudsen GM, Sørensen PS. Neurologi. I: Hansen NE, Haunsø S, Schaffalitzky de Muckadell OB, eds. Medicinsk Kompendium, 16. udgave. København: Nyt Nordisk Forlag, 2004:2505-2703.

Paulson OB, Gjerris F. Introduktion til klinisk neurologisk undersøgelse. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:21-26.

Paulson OB, Gjerris F. Det motoriske system. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:69-112.

Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:1-648.

Sørensen PSS, Paulson OB. Det sensoriske system. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:55-68.

Sørensen PS, Paulson OB. Intoksikationer og ernæringsdeficit. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:537-58.

Vorstrup S, Paulson OB. Defekter i den neuromuskulære transmission. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:585-92.

Willendrup P, Pinborg LH, Hasselbalch SG, Adams KH, Stahr K, Knudsen GM, Svarer C: Assessment of the precision in co-registration of structural MR-images and PET-images with localized binding. Int Congress Series 2004;1265:275-80

2003

Dissertations and PhD theses (1 / 3)
Elfving B. Characterization of serotonin transporter ligands in relation to emission tomography (ph.d-afhandling). København: Eget forlag; 2003:1-102. Forsvaret den 10. januar 2003 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Hasselbalch SG. Quantitation of brain metabolism in humans usings PET-FDG: levels and limitations (disputats). København: Eget forlag; 2003:1-51. Forsvaret den 25. april 2003 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Ma XD. Effect of graded hyperventilation on cerebral blood flow, autoregulation, and metabolism in experimental subarachnoid hemorrhage and acute intracranial hypertension (ph.d-afhandling). København: Eget forlag; 2003:1-139. Forsvaret den 30. juni 2003 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Madsen J. Development of new PET and SPECT ligands for visualization of the serotonin transporter in the brain (ph.d-afhandling). København: Eget forlag; 2003:1-66. Forsvaret den 8. maj 2003 ved Danmarks Farmaceutiske Universitet.

Original publications in peer-reviewed journals (8)
Andersen PB, Krabbe K, Leffers AM, Schmiegelow M, Holm S, Laursen H, Müller JR, Paulson OB. Cerebral glucose metabolism in long-term survivors of childhood primary brain tumors treated with surgery and radiotherapy. J Neurooncol 2003;63:305-13.

Aznar S, Qian Z, Shah R, Rahbek B, Knudsen GM: The 5-HT1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain. Brain Res 2003;959:58-67.

Bay-Hansen R, Ma XD, Hauerberg J, Larsen EH, Juhler M. Effects of cerebrospinal fluid acidity on cerebral blood flow and autoregulation in rats. J Neurosurg Anesth 2003;15:110-8.

Elfving B, Bjørnholm B, Knudsen GM: Interference of anaesthetics with radioligand binding in neuroreceptor studies. Eur J Nucl Med 2003;30:912-5.

Madsen J, Marachtsaki P, Davoodpour P, Bergström M, Långström B, Andersen K, Thomsen C, Martiny L, Knudsen GM. Synthesis and biological evaluation of novel carbon-11-labelled analogues of citalopram as potential radioligands for the serotonin transporter. Bioorg Med Chem 2003;11:3447-56.

Pedersen TF, Paulson OB, Nielsen AH, Strandgaard S. Effect of nephrectomy and captopril on autoregulation of cerebral blood flow in rats. Am J Physiol Heart Circ Physiol 2003;285:1097-104.

Pinborg LH, Adams KH, Svarer C, Holm S, Hasselbalch SG, Haugbøl S, Madsen J, Knudsen GM. Quantification of 5-HT2A receptors in the human brain using [18F]Altanserin-PET and the bolus/infusion approach. J Cereb Blood Flow Metab 2003;23:985-96.

Strauss GI, Møller K, Larsen FS, Kondrup J, Knudsen GM: Cerebral glucose and oxygen metabolism in patients with fulminant hepatic failure. Liver Transpl. 2003;9:1244-52.

Lærebøger, andre oversigtsartikler og ledere
Højgaard L, Eigtved A, Paulson OB. Brain metastases, intracranial lymphomas, and nongliomatous tumors. In: Von Schulthess GK, ed. Clinical molecular anatomic imaging. Philadelphia: Lippincott Williams & Wilkins, 2003:169-74.

Hasselbalch SG. Neuroreceptor imaging with positron emission tomography in dementia. Dementia 2003;4:2-7.

2002

Dissertations and PhD theses (2)
Charlotte Videbæk, cand.med., dr.med. Single photon emission tomography for neuroreceptor studies: Methodological considerations

Trine Fischer Pedersen, cand.scient, PhD. Modulation of cerebral blood flow and its autoregulation by the renin-angiotensin system, in nephrectomized rats

Original publications in peer-reviewed journals (22)
Abildstrom H, Hogh P, Sperling B, Moller JT, Yndgaard S, Rasmussen LS. Cerebral blood flow and cognitive dysfunction after coronary surgery. Ann Thorac Surg 2002;73:1174-8

Balslev D, Nielsen FAA, Frutiger SA, Sidtis JJ, Christiansen TB, Svarer C, Strother SC, Rottenberg DA, Hansen LK, Paulson OB, Law I. Cluster analysis of activity-time series in motor learning. Human Brain Mapping 2002;15:135-45

Bay-Hansen R, Elfving B, Greisen G. Use of near infrared spectroscopy for estimation of peripheral venous saturation in newborns: comparison with co-oximetry of central venous blood. Biol Neonate 2002;82:1-8

Born A P, Law I, Lund T E, Rostrup E, Hanson L G P, Wildschiødtz G, Lou H C, Paulson O B. Cortical deactivation induced by visual stimulation in Human Slow-Wave Sleep. Neuroimage 2002;17:1325-35

Bundesen C, Larsen A., Kyllingsbæk, S, Paulson O B, Law I. Attentional effects in early visual pathways: A whole-brain PET study. Exp Brain Res 2002;147:394-406

Elfving B, Bjørnholm B, Knudsen GM. Predosing with the unlabeled inactive enantiomer as a tool for improvement of the PET signal. Synapse 2002;46:125-127

Gerlach C, Law I, Gade A, Paulson OB. The role of action knowledge in the comprehension of artefacts - A PET study. NeuroImage 2002;15:143-52

Gerlach C, Aaside CT, Humphreys GW, Gade A, Paulson OB, Law I. Brain activity related to integrative processes in visual object recognition: bottom-up integration and the modulatory influence of stored knowledge. Neuropsychologia 2002;40:1254-67

Gerlach C, Law I, Paulson OB. When action turns into words. Activation of motor-based knowledge during categorization of manipulable objects. J Cogn Neuroscience 2002;14:1230-9.

Hansen ES, Hasselbalch S, Law I, Bolwig TG. The caudate nucleus in obsessive-compulsive disorder. Reduced metabolism following treatment with paroxetine: a PET study. Int J Neuropsychopharm 2002;5:1-10

Hesse B, Mehlsen J, Boesen F, Schmidt JF, Andersen EB, Waldemar G, Andersen AR, Paulson OB, Vorstrup S. Regulation of cerebral blood flow in patients with autonomic dysfunction and severe postural hypotension. Clin Physiol & Func Im 2002;22:241-7

Kjær T, Law I, Wildschiødtz G, Paulson, O B, Madsen P L. Regional cerebral blood flow during light sleep - A H215O-PET study. J Sleep Res 2002;11:201-7

Møller K, Paulson OB, Hornbein TF, Colier W, Roach R, Knudsen GM. Unchanged cerebral blood flow and oxidative metabolism after acclimatization to high altitude. J Cereb Blood Flow Metabol 2002; 22:118-26

Møller K, Strauss GI, Thomsen G, Larsen FS, Holm S, Sperling BK, Skinhøj P, Knudsen GM. Cerebral blood flow, oxidative metabolism, and cerebrovascular carbon dioxide reactivity in patients with acute bacterial meningitis. Acta Anaesthesiol Scand 2002;46:567-78

Møller K, Strauss GI, Qvist J, Fonsmark L, Knudsen GM, Larsen FS, Krabbe KS, Skinhøj P, Pedersen BK. Cerebral blood flow and oxidative metabolism during human endotoxemia. J Cereb Blood Flow Metab 2002;22:1262-70

Pedersen TF, Nielsen AH, Strandgaard S, Paulson OB. Nephrectomy and peritoneal dialysis eliminates circulating renin and controls uraemia in the rat. JRAAS 2002;3:130-4

Pinborg LH, Videbæk C, Svarer C, Yndgaard S, Paulson OB, Knudsen GM. Quantification of [123I]PE2I binding to dopamine transporters with SPET. Eur J Nucl Med 2002;29:623-31

Rabiner EA, Messa C, Sargent PA, Husted-Kjaer K, Montgomery A, Lawrence AD, Bench CJ, Gunn RN, Cowen P, Grasby PM. A database of [11C]WAY-100635 binding to 5-HT1A receptors in normal male volunteers: Normative data and relationship to methodological, demographic, physiological, and behavioral variables. Neuroimage 2002;15:620-32

Rasmussen LS, Sperling B, Abildstrom HH, Moller JT. Neuron loss after coronary artery bypass detected by SPECT estimation of benzodiazepine receptors.Ann Thorac Surg 2002;74:1576-80

Rostrup E, Law I, Pott F, Ide K, Knudsen G M. Cerebral hemodynamics measured with simultaneous PET and near-infrared spectroscopy in humans. Brain Res 2002;954:183-93

Schmalbruch IK, Linde R, Paulson OB, Madsen PL. Activation-induced resetting of cerebral metabolism and flow is abolished by ?-adrenergic blockade with propranolol. Stroke 2002;33:251-5

Springborg JB, Ma X, Rochat P, Knudsen GM, Amtorp A, Paulson OB, Juhler M, Olsen NV. A single subcutaneous bolus of erythropoietin normalizes cerebral blood flow autoregulation after subarachnoid hemorrhage in rats. Br J Pharmacol 2002;135:823-9

Lærebøger, andre oversigtsartikler og ledere
Knudsen GM. Funktionel billeddannelse af receptorforandringer ved parkinsonisme: Emissionstomografiske metoder til hjæp i diagnostikken. Ugeskr Laeger 2002;22:2259-62

Knudsen GM, Svarer C. Neuroreceptor imaging: Considerations for design, data analysis, and interpretation. In: Senda M, Kimura Y, Herscovitch P (eds). Brain imaging using PET. San Diego: Academic Press, 2002:p.23-6.

Law I, Roach RC, Olsen NV, Holm S, Nowak M, Hornbein TF, Paulson OB. Oxygen delivery to the brain during behavioral activation at acute normobaric hypoxemia. In: Tomita M, Kanno I, and Hamel E, eds. Brain activation and CBF control. Excerpta Medica. International Congress Series nr 1235, Elsevier Science. 2002, 87 – 98.

Paulson OB, Law I. Hemodynamic and metabolic features of cerebral activation. In: Tomita M, Kanno I, and Hamel E, eds. Brain activation and CBF control. Amsterdam: Elsevier, 2002;205-12.

Paulson OB, Born AP, Bundesen C, Gade A, Gerlach C, Hansen LK, Holm S, Jensen M, Kyllingsbæk S, Larsen A, Law I, Rostrup E, Svarer C. Den arbejdende hjerne - hvordan kan den se ud? Ugeskr Læg 2002;164:2267-75

Paulson OB. Blood-brain barrier, brain metabolism and cerebral blood flow. Eur Neuropsychopharmacol 2002;12:495-501

Willendrup P, Svarer C, Hanson LG, Paulson OB. A simple approach to combined inhomogeneity correction and tissue segmentation of MR MPRAGE images. In: Senda M, Kimura Y, Herscovitch P (eds). Brain imaging using PET. San Diego: Academic Press, 2002:p.159-62.

2001

Dissertations and PhD theses (2)
Møller K. Ph.d.-afhandling 2001: Cerebral blood flow autoregulation in patients with acute bacterial meningitis

Høgh P. Ph.d.-afhandling 2001: Apolipoprotein E (APOE) – genotypens betydning for patofysiologi og sygdomsforløb ved Alzheimer’s sygdom og ved dissemineret sklerose

Original publications in peer-reviewed journals (19)
Aznar S, Knudsen GM: Serotonin induces decrease of 5-HT1A immunoreactivity in organotypic hippocampal cultures. NeuroReport 2001;12:3909-12.

Bech-Azeddine R, Waldemar G, Knudsen GM, Høgh P, Bruhn P, Wildschiødtz G, Gjerris F, Paulson OB, Juhler M. Idiopatic normal-pressure hydrocephalus: evaluation and findings in a multidisciplinary memory clinic. Eur J Neurol 2001;8:601-11.

Blinkenberg M, Rune K, Jensen CV, Ravnborg MH, Kyllingsbæk S, Holm S, Paulson OB, Sørensen PS. Reduceret cerebralt stofskifte korrelerer med MRI-forandringer og kognitiv dysfunktion hos patienter med dissemineret sklerose. Ugeskr Læg 2001;163:3788-92.

Elfving B, Bjørnholm B, Ebert B, Knudsen GM: Binding characteristics of selective serotonin reuptake inhibitors with relation to emission tomography studies. Synapse 2001;41:203-11.

Estrup TM, Paulson OB, Strandgaard. No effect of angiotensin II AT2 receptor antagonist PD123319 on cerebral blood flow autoregulation. JRAAS 2001;2:188-92.

Gerlach C. Structural similarity causes different category-effects depending on task characteristics. Neuropsychologia 2001;39:895-900.

Gruhn N, Larsen FS, Boesgaard S, Knudsen GM, Mortensen SA, Thomsen G, Aldershvile J. Cerebral blood flow in patients with chronic heart failure before and after heart transplantation. Stroke 2001;32: 2530-3.

Hasselbalch SG, Holm S, Pedersen HS, Svarer C, Knudsen GM, Madsen PL, Paulson OB. The 18F-fluorodeoxyglucose lumped constant determined in human brain from extraction fractions of 18F-fluorodeoxyglucose and glucose. J Cereb Blood Flow Metab 2001;21:995-1002.

Hasselbalch SG, Knudsen GM, Capaldo B, Postiglione A, Paulson OB. Blood-brain barrier transport and brain metabolism of glucose during acute hyperglycemia in humans. J Clin Endocrinol Metab 2001;86; 1986-90.

Høgh P, Knudsen GM, Kjaer KH, Jørgensen OS, Paulson OB, Waldemar G. SPECT and apolipoprotein E in Alzheimer’s disease: Impact of the epsilon-4 allele on regional cerebral blood flow. J Geriatr Psychiatry Neurol 2001;14:42-51.

Law I, Jensen M, Holm S, Nickles RJ, Paulson OB. Using 10CO2 for single subject characterization of the stimulus frequency dependence in visual cortex: A novel positron emission tomography tracer for human brain mapping. J Cereb Blood Flow Metab 2001;21:1003-12.

Pinborg LH, Videbæk C, Hasselbalch SG, Sørensen SA, Wagner A, Paulson OB, Knudsen GM. Benzodiazepine receptor quantification in Huntington’s disease with [123I]iomazenil and SPECT. J Neurol Neurosurg Psychiatry 2001;70:657-61.

Schreiber K, Sorensen PS, Koch-Henriksen N, Wagner A, Blinkenberg M, Svarer C, Petersen HC. Correlations of brain MRI parameters to disability in multiple sclerosis. Acta Neurol Scand 2001;104:24-30.

Strauss GI, Møller K, Holm S, Sperling B, Knudsen GM, Larsen FS. Transcranial doppler sonography and internal jugular bulb saturation during hyperventilation in patients with fulminant hepatic failure. Liver Transpl 2001;7:352-8.

Strauss GI, Knudsen GM, Kondrup , Møller K, Larsen FS. Cerebral metabolism of ammonia and amino acids in patients with fulminant hepatic failure. Gastroenterology 2001;121:1109-19.

Strauss GI, Christiansen M, Møller K, Clemmesen JO, Larsen FS, Knudsen GM: S-100b and neuron-specific enolase as markers of cerebral dysfunction in patients with fulminant hepatic failure. Liver Transpl 2001;7:964-70.

Strauss GI, Edvinsson L, Larsen FS, Møller K, Knudsen GM: Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure. Neuropeptides 2001;35:174-80.

Sundgreen C, Larsen FS, Herzog TM, Knudsen GM, Boesgaard S, Aldershvile J. Autoregulation of cerebral blood flow in patients resuscitated from cardiac arrest. Stroke 2001;32:128-32.

Videbæk C, Toska K, Friberg L, Holm S, Angelo HR, Knudsen GM. In vivo measurement of haloperidol affinity to dopamine D2/D3 receptors by [123I]IBZM and single photon emission computed tomography. J Cereb Blood Flow Metab 2001;21:92-7.

Tekstbøger, andre oversigtsartikler og ledere
Strandgaard S, Paulson OB. Hypertension and brain. In: Anand MP, Billimoria AR, eds. Hypertension. An International Monograph 2001. India: IJCP Group, 2001. p. 138-42.

Strandgaard S, Paulson OB. Management of hypertension with cerebrovascular disease. In: Anand MP, Billimoria AR, eds. Hypertension. An International Monograph 2001. India: IJCP Group, 2001. p. 271-3.

2000

Dissertations and PhD theses (2)
Rasmus Linde. Ph.d.-afhandling 2000: Cerebral blood flow and metabolism during acute hyperketonemia.

Christian Gerlach. Ph.d.-afhandling 2000: The functional organization of knowledge and its implementation in the brain.

Original publications in peer-reviewed journals (20)
Blinkenberg M, Rune K, Jensen CV, Ravnborg M, Kyllingsbæk S, Holm S, Paulson OB, Sørensen PS. Cortical cerebral metabolism correlates with MRI lesion load and cognitive dysfunction in MS. Neurology 2000;54:558-64.

Gerlach C, Law I, Gade A, Paulson OB. Categorization and category effects in normal object recognition. A PET Study. Neuropsychologia 2000;38:1693-1703.

Hanson LG, Schaumburg K, Paulson OB. Reconstruction strategy for echo planar spectroscopy and its application to partially undersampled imaging. Magn Reson Med 2000;44:412-7.

Hugdahl K, Law I,Kyllingsbæk S, Brønnick K, Gade A, Paulson OB. Effects of attention on dichotic listening: An 15O-PET study. Hum Brain Mapping 2000;10:87-97.

Høgh P, Oturai A, Schreiber K, Blinkenberg M, Jørgensen OS, Ryder L, Paulson OB, Sørensen PS, Knudsen GM. Apolipoprotein E and multiple sclerosis: impact of the epsilon-4 allele on susceptibility, clinical type and progression rate. Multiple Sclerosis 2000;6:226-30.

Iida H, Law I, Pakkenberg B, Krarup-Hansen A, Eberl S, Holm S, Hansen AK, Gundersen HJG, Thomsen C, Svarer C, Ring P, Friberg L, Paulson OB. Quantitation of regional cerebral blood flow corrected for partial volume effect using O-15 water and PET: I. Theory, error analysis, and stereologic comparison. J Cereb Blood Flow Metab 2000;20:1237-51.

Kofoed KF, Hansen PR, Holm S, Hove JD, Chen K, Jin W, Jensen M, Iida H, Hesse B, Svendsen J, Kelbæk H. Regional myocardial oxygen consumption estimated by carbon-11 acetate and positron emission tomography before and after repetitive ischemia. J Nucl Cardiol 2000;7:228-34.

Kruuse C, Jacobsen TB, Lassen LH, Thomsen LL, Hasselbalch SG, DigePetersen H, Olesen J. Dipyridamole dilates large cerebral arteries concomitant to headache induction in healthy subjects.
J Cereb Blood Flow Metab 2000;20:1372-9.

Kruuse C, Jacobsen TB, Thomsen LL, Hasselbalch SG, Frandsen EK, DigePetersen H, Olesen J. Effects of the non-selective phosphodiesterase inhibitor pentoxifylline on regional cerebral blood flow and large arteries in healthy subjects. Eur J Neurol 2000;7:629-38.

Larsen A, Bundesen C, Kyllingsbæk S, Paulson OB, Law I. Brain activation during mental transformation of size. J Cogn Neurosci 2000;12:763-74.

Larsen FS, Strauss G, Knudsen GM, Herzog TM, Hansen BA, Secher NH. Cerebral perfusion, cardiac output, and arterial pressure in patients with fulminant hepatic failure. Crit Care Med 2000;28:996-1000.

Law I, Iida H, Holm S, Nour S, Rostrup E, Svarer C, Paulson OB. Quantitation of regional cerebral blood flow corrected for partial volume effect using O-15 water and PET: II. Normal values and gray matter blood flow response to visual activation. J Cereb Blood Flow Metab 2000;20:1252-63.

Møller K, Larsen FS, Qvist J, Wandall JH, Knudsen GM, Gjørup IE, Skinhøj P. Dependency of cerebral blood flow on mean arterial pressure in patients with acute bacterial meningitis. Crit Care Med 2000;28:1027-32.

Møller K, Høgh P, Larsen FS, Strauss GI, Skinhøj P, Sperling BK, Knudsen GM. Regional cerebral blood flow during hyperventilation in patients with acute bacterial meningitis. Clin Physiol 2000;5:399-410.

Møller K, Skinhøj P, Knudsen GM, Larsen FS: Effect of short-term hyperventilation on cerebral blood flow autoregulation in patients with acute bacterial meningitis. Stroke 2000;31:1116-22.

Nour S, Svarer C, Kristensen JKI, Paulson OB, Law I. Cerebral activation during micturition in normal men. Brain 2000;123:781-9.

Pinborg LH, Videbæk C, Knudsen GM, Swahn C-G, Halldin C, Friberg L, Paulson OB, Lassen NA. Dopamine D2 receptor quantification in extrastriatal brain regions using [123I]Epidepride with bolus/infusion. Synpase 2000;36:322-9.

Rostrup E, Law I, Blinkenberg M, Larsson HBW, Born AP, Holm S, Paulson OB. Regional differences in the CBF and BOLD responses to hypercapnia: A combined PET and fMRI study. NeuroImage 2000;11:87-97.

Sargent PA, Kjær KH, Bench CJ, Rabiner EA, Messa C, Meyer J, Gunn RN, Grasby PM, Cowen PJ. Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment. Arch Gen Psychiatry 2000;57:174-80.

Videbæk C, Toska K, Scheideler MA, Paulson OB, Knudsen GM. SPECT tracer [123I]IBZM has similar affinity to dopamine D2 and D3 receptors. Synapse 2000;38:338-42.

Tekstbøger, andre oversigtsartikler og ledere
Gjedde A, Hansen SB, Knudsen GM, Paulson OB, eds. Physiological imaging of the brain with PET. San Diego: Academic Press 2000.

Iida H, Law I, Pakkenberg B, Eberl S, Paulson OB. Quantitation of regional cerebral blood flow corrected for partial volume effect using O-15 water and PET. In: Tamaki N, Tsukamoto E., Kuge Y, Katoh C. and

Morita K, eds. Positron Emission Tomography in the Millennium. Elsevier Science. 2000; 245.

Knudsen GM, Paulson OB. Neurologiske og neuromuskulære sygdomme. I: Lorenzen I, Bendixen G, Hansen NE, eds. Medicinsk Kompendiums Lommebog, 2. udgave. København: Nyt Nordisk Forlag Arnold Busck A/S, 2000:496-538.

Spence JD, Paulson OB, Strandgaard S. Hypertension and stroke. In: Messerli FH, ed. The ABCs of antihypertensive therapy. New York: Lippincott Williams & Wilkins, 2000:279-96.

1999

Dissertations and PhD theses (2)
Larsen FS. Ph.d.-afhandling: High volume plasmapheresis in acute liver failure .

Schmalbruch I. Ph.d.-afhandling: A physiological and biochemical study on cerebral metabolism before, during and after physiological and amphetamine-induced activation and the effect of propranolol.

Original publications in peer-reviewed journals (14)
Blinkenberg M, Jensen CV, Holm S, Paulson OB, Sørensen PS. A longitudinal study of cerebral glucose metabolism, MRI, and disability in patients with MS. Neurology 1999;53:149-53.

Gerlach C, Law I, Gade A, Paulson OB. Perceptual differentiation and category effects in normal object recognition. A PET study. Brain 1999;122:2159-70.

Hansen LK, Larsen J, Nielsen FÅ, Strother SC, Rostrup E, Savoy R, Lange N, Sidtis J, Svarer C, Paulson OB. Generalizable patterns in neuroimaging: How many principal components? NeuroImage 1999;9:534-44.

Hasselbalch SG, Knudsen GM, Videbæk C, Pinborg LH, Schmidt JF, Holm S, Paulson OB. No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans. Diabetes 1999;48:1915-21.

Herholz K, Nordberg A, Salmon E, Perani D, Kessler J, Mielke R, Halber M, Jelic V, Almkvist O, Collette F, Alberoni M, Kennedy A, Hasselbalch S, Fazio F, Heiss W. Impairment of neocortical metabolism predicts progression in Alzheimer's disease. Dementia Geriatr Cogn Disord Nov-Dec; 10(6): 494-504; 1999.

Hugdahl K, Brønnick K,Kyllingsbæk S, Law I, Gade A, Paulson OB. Brain activation during dichotic presentations of consonant-vowel and musical instrument stimuli: a 15O-PET study. Neuropsychologia 1999;37:431-40.

Høgh P, Waldemar G, Knudsen GM, Bruhn P, Mortensen H, Wildschiødtz G, Bech RA, Juhler M, Paulson OB. A multidisciplinary memory clinic in a neurological setting: diagnostic evaluation of 400 consecutive patients. Eur J Neurol 1999;6:279-88.

Kim S, Rostrup E, Larsson HBW, Ogawa S, Paulson OB. Determination of relative CMRO2 from CBF and BOLD changes: Significant increase of oxygen consumption rate during visual stimulation. Magn Reson Med 1999;41:1152-61.

Kjems U, Strother SC, Anderson J, Law I, Hansen LK. Enhancing the multivariate signal of [15O] water PET studies with a new nonlinear neuroanatomical registration algorithm. IEEE Transactions on Medical Imaging 1999;18:306-19.

Knudsen GM, Hasselbalch SG, Hertz MM, Paulson OB. High dose insulin does not increase glucose transfer across the blood-brain barrier in humans: a re-evaluation. Eur J Clin Invest 1999;29(8):687-91.

Linde R, Schmalbruch IK, Paulson OB, Madsen PL. The Kety-Schmidt technique for repeated measurements of global cerebral blood flow and metabolism in the conscious rat. Acta Physiol Scand 1999;165:395-401.

Nowak M, Olesen KS, Law I, Holm S, Paulson OB, Secher NH. Command-related distribution of regional cerebral blood flow during attempted handgrip. J Appl Physiol 1999;86(3):819-24.

Strauss GI, Høgh P, Møller K, Knudsen GM, Hansen BA, Larsen FS. Regional cerebral blood flow during mechanical hyperventilation in patients with fulminant hepatic failure. Hepatology 1999;30:1368-1373.

Videbæk C, Ott P, Paulson OB, Knudsen GM. Blood-brain barrier transport and protein binding of flumazenil and iomazenil in the rat: Implications for neuroreceptor studies. J Cereb Blood Flow Metab 1999;19:948-55.

Tekstbøger, andre oversigtsartikler og ledere
Knudsen GM, Hasselbalch SG, Paulson OB. Induction of carrier mediated transport across the human blood-brain barrier. In: Paulson OB, Knudsen GM, Moos T, eds. Brain Barrier Systems. Copenhagen: Munksgaard 1999:321-38.

Knudsen GM, Paulson OB. In: Lorenzen I, Bendixen G, Hansen NE, eds. Medicinsk Kompendium. Multiple Choice. Copenhagen: Nyt Nordisk Forlag 1999:164-73.

Paulson OB, Boysen G, Krarup C, Knudsen GM, Sørensen PS. Neurologi. I: Lorenzen I, Bendixen G, Hansen NE, eds. Medicinsk Kompendium, 15. udgave. København: Nyt Nordisk forlag Arnold Busck A/S 1999:2481-2677.

Paulson OB, Knudsen GM, Moos T, eds. Brain Barrier Systems. Alfred Benzon Symposium 45. Copenhagen: Munksgaard 1999:1-524.

Strandgaard S, Paulson OB. Hypertension and brain. In: Anand MP, Billimoria AR, eds. Hypertension - An international monograph 2000. New Delhi: IJCP Group of Publications, 1999:133-8.

Strandgaard S, Paulson OB. Management of hypertension with cerebrovascular disease. In: Anand MP, Billimoria AR, eds. Hypertension - An international monograph 2000. New Delhi: IJCP Group of Publications, 1999:233-6.

Sørensen PS, Paulson OB, Gjerris F. Nervesystemets sygdomme. 2. udgave. København: FADL, 1999.

1998

Dissertations and PhD theses (3)
Larsen FS. Cerebral circulation in liver failure. Cerebral circulation in liver failure: Ohm's law in force. Semin Liver Dis 1996;16:281-92. (Trykt i 1996 men forsvaret januar 1998).

Lassen U. Positron emission tomography (PET) of malignant tumors. Ph.d.-afhandling.

Mørch N.A multivariate approach to functional neuro modeling. Ph.d.-afhandling.

Original publications in peer-reviewed journals (7)
Hasselbalch SG, Madsen PL, Knudsen GM, Holm S, Paulson OB. Calculation of the FDG lumped constant by simultaneous measurements of global glucose and FDG metabolism in humans. J Cereb Blood Flow Metab 1998;18:154-60.

Jernigan T, Ostergaard AL, Law I, Svarer C, Gerlach C, Paulson OB. Brain activation during word identification and word recognition. Neuroimage 1998;8:93-105.

Lassen U, Andersen P, Daugaard G, Holm S, Jensen M, Svarer C, Poulsen HS, Paulson OB. Metabolic and hemodynamic evaluation of brain metastases from small cell lung cancer with positron emission tomography. Clin Cancer Res 1998;4:2591-7.

Law I, Svarer C, Rostrup E, Paulson OB. Parieto-occipital cortex activation during self-generated eye movements in the dark. Brain 1998;121:2189-2200.

Madsen PL, Linde R, Hasselbalch SG, Paulson OB, Lassen NA. Activation-induced resetting of cerebral oxygen and glucose uptake in the rat. J Cereb Blood Flow Metab 1998;18:742-8.

Strauss G, Hansen BA, Knudsen GM, Larsen FS. Hyperventilation restores cerebral blood flow autoregulation in patients with acute liver failure. J Hepatol 1998;28:199-203.

Vraamark T, Waldemar G, Paulson OB. Differential effects of migraine drugs on cerebral blood flow. Cephalalgia 1998;18:306-12.

Tekstbøger, andre oversigtsartikler og ledere
Ardekani BA, Strother SC, Anderson JR, Law I, Paulson OB, Kanno I, Rottenberg DA. On the detection of activation patterns using principal components analysis. In: Carson RE, Daube-Witherspoon ME,

Herscovitch P, eds. Quantitative functional brain imaging with positron emission tomography. San Diego: Academic Press 1998:253-7.

Baron JC (chairman), Lenzi GL, Brücke T, Frackowiak R, Heiss WD, Pantano P, Paulson OB, Rossini PM, Schoenen J, Touboul PJ, Vion-Dury J, Von Kummer R. European Federation of Neurological Societies
Task Force on Neuroimaging: Neuroimaging in European academic neurology: present status and future organization. Eur J Neurol 1998;5:5-15.

Knudsen GM, Paulson OB. Measurement of blood-brain barrier in humans using indicator diffusion. In: Pardridge WM, ed. Introduction to the blood-brain barrier. Methodology, biology and pathology. Cambridge: Cambridge University Press 1998:133-9.

Olsen KS. The influence of ketanserin on cerebral hemodynamics - with special reference to neuroanesthesia. Dan Med Bull 1998;45:76-88.

Paulson OB. Hjernens blodforsyning. Ugeskr Læger 1998:11:1612-13.

1997

Dissertations and PhD theses (1 / 2)
Blinkenberg M. Ph.d.-afhandling. Regional cerebral metabolism in patients with multiple sclerosis.

Law I. Ph.d.-afhandling. Saccadic eye movements. A functional brain mapping approach.

Olsen KS. Disputats. The influence of ketanserin on cerebral hemodynamics - with special reference to neuroanesthesia. København: Lægeforeningens Forlag 1997.

Original publications in peer-reviewed journals (6)
Bay-Hansen J, Ravn T, Knudsen GM. Application of interhemispheric index for transcranial doppler sonography velocity measurements and evaluation of recording time. Stroke 1997;28:1009-14.

Bergström KA, Halldin C, Yu MX, Swahn C-G, Åkerman KK, Hiltunen J, Tiihonen J, Kuikka J, Lassen N, Videbæk C, Farde L. The metabolite pattern of [123I]epidepride in human plasma determined with a gradient HPLC method. J Label Comp Radiopharm 1997;40:151-3.

Law I, Svarer C, Holm S, Paulson OB. The activation pattern i n normal humans during suppression, imagination and performance of saccadic eye movements. Acta Physiol Scand 1997;161:419-34.

Mørch N, Hansen LK, Strother SC, Svarer C, Rottenberg DA, Lautrup B, Savoy R, Paulson OB. Nonlinear versus linear models in functional neuroimaging: Learning curves and generalization crossover. In:

Duncan J, Gindi G, eds. Information Processing in Medical Imaging. Berlin Heidelberg: Springer Verlag. Lecture notes in computer science 1997;1230:259-70.

Vraamark T, Waldemar G, Edvinsson L, Paulson OB. Differential effects of increasing doses of alfa-trinositol on cerebral blood flow autoregulation. Pharmacol & Toxicol 1997;80:38-43.

Tekstbøger, andre oversigtsartikler og ledere
Lassen NA, Paulson OB. Indomethacin nedsætter hjernegennemblødningen og det intrakranielle tryk. Ugeskr Læger 1997;159:4249.

Paulson OB, Hasselbalch SG. Blood-brain barrier transport of glucose: adaptation to changes in blood glucose levels. Nutr Metab Cardiovasc Dis 1997;7:217-24.

Paulson OB, Lassen NA. SPECT og PET i neurobiologien. Nord Med 1997;112:356-60.

Paulson OB, Lassen NA. SPECT og PET i neurobiologien. Ugeskr Læger 1997;159/16:2351-5.

Strandgaard S, Paulson OB. The cerebral circulation in hypertension. In: Zanchetti A, Mancia G, eds. Pathophysiology of hypertension. Amsterdam: Elsevier Science 1997;17:265-94.

Waldemar G, Høgh P, Paulson OB. Functional brain imaging with SPECT in the diagnosis of Alzheimer’s disease. Intern Psychoger 1997/Suppl 1;9:223-7.

1996

Dissertations (1)
Waldemar G. Functional brain imaging with SPECT in normal aging and dementia. Methodological, pathophysiological, and diagnostic aspects. Cerebrovasc Brain Metab Rev 1995;7:89-130 (antaget og forsvaret i 1996).

Original publications in peer-reviewed journals (9)
Andersen AR, Hansen BR, Høgenhaven H, Herning M, Paulson O, Dam M. Interictal SPECT of rCBF is of clinical utility in the preoperative evaluation of patients with partial epilepsy. Epilepsy Res 1996;25:41-50.

Blinkenberg M, Bonde C, Holm S, Svarer C, Andersen J, Paulson OB, Law I. Rate dependence of regional cerebral activation during performance of a repetitive motor task: a PET study. J Cereb Blood Flow Metab 1996;16:794-803.

Blinkenberg M, Rune K, Jønsson A, Holm S, Jensen CV, Paulson OB, Sørensen PS. Cerebral metabolism in a case of multiple sclerosis with acute mental disorder. Acta Neurologica Scandinavica 1996;94:310-3.

Boller F, Duyckaerts C, Paulson OB, Vorstrup S, Soelberg Sørensen P. Prion related diseases and Creutzfeldt-Jakob disease (subacute spongiform encephalopathy). Eur J Neurol 1996;3:485-6.

EU concerted action on functional imaging: Poline J-B, Vandenberghe R, Holmes AP, Friston KJ, Frackowiak RSJ et al. Reproducibility of PET activation studies: Lessons from a multi-center European experiment. Neuroimage 1996;4:34-54.

Hasselbalch SG, Madsen PL, Hageman LP, Olsen KS, Justesen N, Holm S, Paulson OB. Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia. Am J Physiol 1996;270 (Endocrinol Metab 33):E746-51.

Hasselbalch SG, Knudsen GM, Holm S, Hageman LP, Capaldo B, Paulson OB. Transport of d-glucose and 2-fluorodeoxyglucose across the blood-brain barrier in humans. J Cereb Blood Flow Metabol 1996;16:659-66.

Hasselbalch S, Knudsen GM, Toft PB, Høgh P, Tedeschi E, Holm S, Videbæk C, Henriksen O, Lou HC, Paulson OB. Cerebral glucose metabolism is decreased in white matter changes in patients with phenylketonuria. Pediatr Res 1996;40:21-4.

Larsen FS, Hansen BA, Ejlersen E, Secher NH, Clemmesen JO, Tygstrup N, Knudsen GM. Cerebral blood flow, oxygen metabolism and transcranial Doppler sonography during high-volume plasmapheresis in fulminant hepatic failure. Eur J Gastroenterol Hepatol 1996;8:261-65.

Larsen FS, Hansen BA, Pott F, Ejlersen E, Secher NH, Paulson OB, Knudsen GM. Dissociated cerebral vasoparalysis in acute liver failure. J Hepatol 1996;25:145-151.

Tekstbøger, andre oversigtsartikler og ledere
Gjerris F, Paulson OB. Centralnervesystemets kirurgiske sygdomme. I: Hald T, Stadil F, eds. Kirurgisk Kompendium. 2. udgave. København: Nyt Nordisk Forlag Arnold Busck 1996:355-402.

Gjerris F, Paulson OB. Degenerative osteoartrotiske sygdomme i columna, diskusprolaps og kirurgiske sygdomme i det perifere nervesystem. I: Hald T, Stadil F, eds. Kirurgisk Kompendium, 2. udgave. København: Nyt Nordisk Forlag Arnold Busck 1996:433-59.

Knudsen GM, Paulson OB. Neurologiske og neuromuskulære sygdomme. I: Lorenzen I, Bendixen G, Hansen NE, eds. Medicinsk Kompendiums Lommebog. København: Nyt Nordisk Forlag Arnold Busck A/S, 1996:415-52.

Paulson OB. De neurologiske artikler. I: Holm-Nielsen N, ed. Klinisk Ordbog. København: Munksgaard 1996.

Paulson OB. Billeddiagnostik af hjernens funktion. Lundbeckfonden "Årsberetning 1995" 1996:18-19.

Paulson OB, Gjerris F, Sørensen PS, Juhler M. Klinisk neurologi og neurokirurgi. 2. udg. København: FADL, 1996.

Strandgaard S, Paulson OB. Antihypertensive drugs and cerebral circulation. Eur J Clin Invest 1996;26-625-30.

Vorstrup S, Paulson OB. Prionsygdomme. Ugeskr Læger 1996;158:4061.

Vorstrup S, Haase J, Waldemar G, Andersen A, Schmidt J, Paulson OB. EC-IC bypass in patients with chronic hemodynamic insufficiency. Acta Neurol Scand 1996/Suppl 166:79-81. Kongresmeddelelser
European concerted action on functional imaging, Cologne, Copenhagen, Düsseldorf, Essen, Groeningen Leuven, Liege, London, Lyon, Milan, Orsay, Stockholm (Rapporteur: J-B. Poline). Analyzing a European PET activation study. Lessons from a multi-center experiment. In: Myers R, Cunningham V, Bailey D, Jones T, eds. Quantification of brain function using PET. London: Academic Press 1996:372-7.

Holm S, Law I, Paulson OB. 3D PET activation studies with an H215O bolus injection. In: Myers R, Cunningham V, Bailey D, Jones T, eds. Quantification of brain function using PET. San Diego: Academic Press, 1996:93-7.

Larsen J, Hansen LK, Svarer C, Ohlsson M. Design and regularization of neural networks: The optimal use of a validation set. In: Usui S et al., eds. Neural networks for signal processing VI. Piscataway, NJ: IEEE, 1996:62-71.

Rostrup E, Law I, Blinkenberg M, Larsson HBW, Born P, Paulson OB. A combined PET and MRI study of human CBF in hypercapnia. Proceedings of the International Society for Magnetic Resonance in Medicine. Fourth International Meeting and Exhibition 1996, S1762.

Svarer C, Law I, Holm S, Mørch N, Hasselbalch S, Hansen LK, Paulson OB. An artificial neural network approach to estimation of the regional glucose metabolism using PET. In: Myers R, Cunningham V, Bailey D, Jones T, eds. Quantification of brain function using PET. San Diego: Academic Press, 1996:271-6.